CAS: 18368-64-4; 2-Chloro-5-Methylpyridine

相似化合物

58584-94-4 18368-76-8 263012-63-1

上下游产品

CAS号108-99-6 3-甲基吡啶 | CAS号123-38-6 丙醛 | CAS号1003-73-2 3-甲基吡啶-N-氧化物 | CAS号1498-51-7 二氯磷酸乙酯 | CAS号1603-41-4 2-氨基-5-甲基吡啶 | CAS号75-44-5 光气 | CAS号98-88-4 苯甲酰氯 | CAS号761-65-9 N,N-二丁基甲酰胺 | CAS号88-95-9 邻苯二甲酰氯 | CAS号1003-68-5 2-羟基-5-甲基吡啶 | CAS号55876-84-1 5-溴甲基吡啶-2-甲酸甲酯 | CAS号92028-39-2 5-甲基-2-(苯基甲氧基)吡啶 | CAS号20173-49-3 2-氯-5-甲基吡啶-N-氧化物 | CAS号18368-58-6 5-甲基-2(1H)-吡啶硫酮 | CAS号85237-65-6 2-(4-氟苯基)-5-甲基吡啶 | CAS号58757-38-3 6-氯吡啶-3-羰酰氯 | CAS号5326-23-8 6-氯烟酸 | CAS号66909-30-6 2-氯-5-甲基烟酸 | CAS号6271-78-9 6-氯烟酰胺 | CAS号70258-18-3 2-氯-5-氯甲基吡啶

2-羟基-5-甲基嘧啶置于4-二甲氨基吡啶,氯化亚砜,三光气体系中,化学反应 4.0H,以95%的收率获得2-氯-5-甲基吡啶
参考文献:氮杂氮杂戊烯的高效无磷氯化反应及其在一锅法药物合成中的应用
标题:氮杂氮杂戊烯的高效无磷氯化反应及其在一锅法药物合成中的应用
摘要:用碳酸二(三氯甲基)酯(btc)和socl 2氯化羟基氮杂芳烃已经通过与5重量%的4-二甲基氨基吡啶(dmap)作为催化剂回流而有效地进行.各种底物都可以高产率氯化.所获得的氯化氮杂芳烃可通过简单的后处理直接直接用于大规模的一锅合成.
Doi:10.1021/acs.Oprd.9B00407

专利信息

专利号:US-2023286918-A1
优先权日:2020-07-02
标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat
发明人：JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER
权利人:AKEBIA THERAPEUTICS INC
摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.

专利号:US-4658031-A
优先权日:1982-10-07
标 题:Synthesis of 2-substituted-5-methyl-pyridines and intermediates therefor
发明人：HARTMANN LUDWIG A; STEPHEN JOHN F
权利人:ICI AMERICA INC
摘要:A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicies as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:US-4584380-A
优先权日:1982-10-07
标 题:Synthesis of 2-substituted-5-methyl-pyridines and intermediates therefor
发明人：HARTMANN LUDWIG A; STEPHEN JOHN F
权利人:ICI AMERICA INC
摘要:A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicides as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.

专利号:US-4473696-A
优先权日:1982-10-07
标题:Synthesis of 2-substituted-5-methyl-pyridines
发明人：HARTMANN LUDWIG A; STEPHEN JOHN F
权利人:ICI AMERICA INC
摘要:A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicides as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.

专利号:US-4687854-A
优先权日:1982-10-07
标 题 :Bispiperidone precursor of 2-substituted-5-methyl-pyridines
发明人：HARTMANN LUDWIG A; STEPHEN JOHN F
权利人:ICI AMERICA INC
摘要:A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicides as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two radily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.