CAS: 17350-84-4; (R)-2-Amino-2-Methyl-3-Phenylpropanoic Acid

相似化合物

23239-35-2 1132-26-9 135944-05-7

上下游产品

CAS号22435-99-0 (R)-2-氨基-3-邻甲苯丙酸乙酯 | CAS号110510-49-1 tert-butyl 2-me... | CAS号100-39-0 溴化苄 | CAS号110510-46-8 (R)-tert-butyl ... | CAS号608538-70-1 (R)-3-benzyl-7-... | CAS号111771-58-5 (R)-2-((叔丁氧基羰基)...

📜D-苯丙氨酸置于盐酸,Sodium Hydroxide,Potassium Trimethylsilonate,Lithium Hexamethyldisilazane体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 78.5H,反应生成α-甲基-D-苯丙氨酸
参考文献:Potassium Trimethylsilanolate Induced Cleavage Of 1,3-Oxazolidin-2-And 5-Ones,And Application To The Synthesis Of (R)-Salmeterol
标题:Potassium Trimethylsilanolate Induced Cleavage Of 1,3-Oxazolidin-2-And 5-Ones,And Application To The Synthesis Of (R)-Salmeterol
摘要:描述了一种使用四氢呋喃中的三甲基硅醇钾裂解1,3-噁唑烷-5-酮和1,3-噁唑烷-2-酮的便捷高效方法.在反应条件下,苄氧羰基保护基易于脱除,而n-苯甲酰基则保持稳定.文中还描述了以2-噁唑烷酮环作为乙醇胺片段保护基合成(R)-沙美特罗的方法.
Doi:10.1039/b212454H

专利信息

专利号:WO-2008098280-A1
优先权日:2007-02-16
标题:Methods for the synthesis of dicarba bridges in growth hormone peptides
发明人：ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
权利人:POLYCHIP PHARMACEUTICALS PTY; UNIV MONASH; ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
摘要:The invention relates to peptides comprising the carboxy terminal sequence of a growth hormone or an analogue of such a peptide in which the disulfide bridge is replaced by a dicarba bridge. Compositions containing such dicarba bridged peptides and method of treating obesity in an animal such as a human comprising administration of such dicarba bridged peptides are also disclosed.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:KR-20230118799-A
优先权日:2020-08-06
标题 :Chemical Synthesis of Large Enantiomer Proteins and Uses Thereof