专利号:US-5124478-A 优先权日:1987-12-22 标 题:Acid-labile anchor groups for the synthesis of peptide amides by a solid-phase method 发明人:BREIPOHL GERHARD; KNOLLE JOCHEN; STUEBER WERNER 权利人:HOECHST AG 摘要:The invention relates to new compounds of the formula ##STR1## in which R 1 denotes (C 1 -C 8 )-alkyl, R 2 denotes an amino acid residue which is protected with a urethane protective group which can be eliminated with weak acid or base, or denotes an amino protective group which can be eliminated with weak acid or base, R 3 denotes hydrogen or (C 1 -C 4 )-alkyl, and Y 1 -Y 9 denote identical or different radicals hydrogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy or --O--(CH 2 ) n --COOH (with n=1 to 6), with one of these radicals being --O--(CH 2 ) n --COOH, or Y 1 , Y 2 and Y 5 -Y 9 denote identical or different radicals hydrogen, (C 1 -C 4 )-alkyl or (C 1 -C 4 )-alkoxy, Y 3 denotes hydrogen or (C 1 -C 8 )-alkoxy and Y 4 denotes --(CH 2 ) n --COOH or --NH--CO--(CH 2 ) n --COOH (with n=1 to 6). n Processes for the preparation thereof and the synthesis of peptide amides by a solid-phase method using these new compounds (spacers) are described.
专利号:US-11746364-B2 优先权日:2018-01-17 标题 :Enzymatic synthesis of kavalactones and flavokavains 发明人:PLUSKAL TOMÃ?S; Weng jing-ke 权利人:WHITEHEAD INST BIOMEDICAL RES 摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.
专利号:PT-89297-B 优先权日:1987-12-22 标题 :METHOD FOR PREPARING NEW INTERMEDIATE COMPOUNDS FOR PEPTIDE SYNTHESIS AND PROCESS FOR SYNTHESIS OF PEPTIDE-AMIDES BY THE SOLID PHASE METHOD USING THE REFERRED COMPOUNDS
专利号:US-2019271015-A1 优先权日:2018-01-17 标题 :Enzymatic synthesis of kavalactones and flavokavains
专利号:US-10941429-B2 优先权日:2018-01-17 标 题:Enzymatic synthesis of kavalactones and flavokavains
专利号:IL-88741-A 优先权日:1987-12-22 标 题:Aromatic compounds used for the synthesis of peptides and the process of producing peptides using such compounds
参考标题:Copper Catalyzed Cross-Coupling Reactions Of Carboxylic Acids: An Expedient Route To Amides, 5-Substituted γ-Lactams And α-Acyloxy Esters 作者:S. Priyadarshini,P. J. Amal Joseph,M. Lakshmi Kantam 摘要:A Convenient And Recyclable Catalytic Protocol For The Synthesis Of N,N-Dimethyl Substituted Amides, 5-Substituted γ-Lactams And α-Acyloxy Ethers From Carboxylic Acids Using Cuo Nanoparticles And Tbhp Is Described.
合成参考文献
摘要:I. Hsu and L. F. Koons, J. Indian Chem. Soc. 44, 540 (1967). 参考文献:10.1186/s12934-015-0353-y 摘要:Sim GY, Yang S, Kim BG, Ahn J. Bacterial synthesis of N-hydroxycinnamoyl phenethylamines and tyramines. Microbial Cell Factories. 2015 Oct 13;14(1):162. doi: 10.1186/s12934-015-0353-y.