CAS: 15572-56-2; Propan-2-Amine Hydrochloride

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29552-58-7 102-97-6 5824-40-8

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CAS号563-83-7 异丁酰胺 | CAS号71847-21-7 Diphenylphosphi... | CAS号102095-58-9 tert-butyl diet... | CAS号4707-95-3 叔丁基二氯磷酸 | CAS号75-31-0 异丙胺 | CAS号3615-24-5 异丙氨基比林 | CAS号85894-35-5 N-Nitroso-N-iso... | CAS号28049-80-1 (i-Pr2N)2BCl | CAS号10574-68-2 3-propan-2-yl-2... | CAS号537-21-3 氯丙胍 | CAS号500-92-5 氯胍 | CAS号996-35-0 二甲基异丙胺 | CAS号1484-09-9 9-异丙基-9H-咔唑 | CAS号16728-80-6 2-(异丙基氨基)乙腈 | CAS号26118-67-2 异丙基氨基磺酰氯 | CAS号691-60-1 异丙基脲 | CAS号44830-55-9 氯胍杂质A | CAS号4128-37-4 1,3-二异丙基脲

📜2-硝基丙烷置于c36H56Cl3Crn2O,Magnesium,频那醇硼烷,盐酸体系中,用 四氢呋喃,水,乙酸乙酯 用作溶剂,化学反应 24.0H,以86%的收率获得异丙基氨盐酸盐
参考文献:用铬催化的环状(烷基)(氨基)卡宾配体促进的硝基脱氧硼氢化反应:范围,机制和应用
标题:用铬催化的环状(烷基)(氨基)卡宾配体促进的硝基脱氧硼氢化反应:范围,机制和应用
摘要:利用 N-杂环卡宾作为非无害配体促进转化的过渡金属催化尚未得到很好的研究.我们在这里报告了具有成本效益的铬催化的环状(烷基)(氨基)卡宾(caac)配体促进的硝基脱氧硼氢化反应.使用 1 Mol % 的 Caac-Cr 预催化剂,将 Hbpin 添加到硝基支架上会导致脱氧,从而保留各种可还原的官能团和敏感基团对硼氢化的相容性,从而提供一种温和,化学选择性和易于形成的策略苯胺,以及杂芳基和脂肪胺衍生物,具有广泛的范围和特别高的转换数(高达 1.8 x 106).基于理论计算的机械研究,表明caac配体在促进hbpin氢化物极性反转中起重要作用;它用作 H 穿梭以促进脱氧硼氢化.通过这种策略制备的几种市售药物突出了其在药物化学中的潜在应用.
Doi:10.1021/jacs.0C12318

专利信息

专利号:US-2025188502-A1
优先权日:2022-03-10
标 题 :Biocatalyst and method for the synthesis of ubrogepant intermediates
发明人：CHEN HAIBIN; HU HU; CAI BAOQIN; XU JUNPENG; LIU SITONG; JIN LUPING; WU XINWEI; CUI QINYAN; ZHANG CHENGXIAO; ZHU KAILONG
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:This application provides engineered transaminase polypeptides for the synthesis of Ubrogepant intermediates with high stereoselectivity, high catalytic activity and good stability. This application also provides a reaction process for the asymmetric synthesis of Ubrogepant intermediates using the transaminase polypeptide.

专利号:US-11459549-B2
优先权日:2018-05-10
标 题:Method for biocatalytic synthesis of Sitagliptin and intermediate thereof
发明人：WU FAHAO; YANG WEN; LI GANG; SHI HONGWEI; GAO YANGZHE; LIU LILI; YUAN ZHIFA
权利人:CHINA FORTUNE WAY COMPANY; NANJING REDWOOD FINE CHEMICAL CO LTD
摘要:Provided is a method for biocatalytic synthesis of Sitagliptin and intermediates thereof, in particular, provided are compounds of Formula (I) and Formula (II), or pharmaceutically acceptable salts thereof, a polypeptide capable of catalyzing conversion of a compound of Formula (I) to a compound of Formula (II), a nucleic acid encoding the polypeptide, a vector and a cell comprising the nucleic acid. In addition, also provided are a method for producing a compound of Formula (II) and Sitagliptin by using the polypeptide and the compound of Formula (I), and a method for preparing the polypeptide.

专利号:US-6133018-A
优先权日:1997-06-02
标 题 :Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE L; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:EP-1075534-B8
优先权日:1998-03-11
标 题 :Improvements in the enzymatic synthesis of chiral amines
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:WO-2023112055-A1
优先权日:2021-12-15
标 题 :New synthetic process design for the synthesis of carboxy tormifene and purity analysis to strengthen antidoping testing
发明人：KUMAR GANGASANI JAGADEESH; PAWAR SACHIN DATTRAM; RADHAKRISHNANAND PULLAPANTHULA; MURTY UPADHYAYULA SURYANARAYANA; SAHU PURAN LAL; DUBEY SACHIN; SAHU KAPENDRA; UPADHYAY AWANISH; KUMAR PRAMOD
权利人:DIRECTOR NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RES GUWAHATI NIPER G; DIRECTOR NAT DOPE TESTING LABORATORY NDTL
摘要:The present invention relates to a process for preparing a compound of formula I: I. The compound of formula I is useful in anti-doping tests.

专利号:US-10329268-B2
优先权日:2013-09-13
标 题 :Processes for preparing medicaments for the treatment of cardiovascular diseases and intermediates for use therein
发明人：RUSSO DOMENICO; WAHNON JORGE; MATON WILLIAM; WEBER BEAT T; JERONIMO PAULA; SOUSA LUISA; BARROCAS PEDRO; PIRES RITA; LIMA RICARDO; VASCONCELOS TEOFILO
权利人:BIAL PORTELA & CA SA
摘要:The present invention provides a compound of formula N wherein: X is CH 2 , oxygen or sulphur; R 1 , R 2 and R 3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino or dialkylamino group, wherein N is in the form of the individual R- and S-enantiomer or a mixture of the (R)- and (S)-enantiomer. The present invention also provides a compound of formula MA. The present invention also provides processes for preparing the above compounds, and processes involving their use. The compounds are particularly useful as intermediates in the synthesis of peripherally-selective inhibitors of dopamine-β-hydroxylase.