CAS: 1204-21-3; 2-Bromo-2',5'-Dimethoxyacetophenone

相似化合物

31949-21-0 60965-26-6 1549327-88-9

上下游产品

CAS号1201-38-3 2,5-二甲氧基苯乙酮 | CAS号598-21-0 溴乙酰溴 | CAS号150-78-7 对苯二甲醚 | CAS号100849-94-3 6-(2,5-dimethox... | CAS号3600-87-1 2-氨基-1-(2,5-二甲氧... | CAS号911047-42-2 ethyl 2-(2,5-di... | CAS号898787-03-6 2,5-二甲氧基苯甲酰基乙腈 | CAS号74605-12-2 4-(2,5-二甲氧基苯基)-... | CAS号60407-53-6 alpha-(氨基甲基)-2,... | CAS号100849-95-4 3-(2,5-dimethox... | CAS号1201-38-3 2,5-二甲氧基苯乙酮 | CAS号89654-17-1 1-(2,5-dimethox...

2,5-二甲氧基苯乙酮置于氢溴酸,溴,溶剂黄146体系中,化学反应生成2-溴-2',5'-二甲氧基苯乙酮
参考文献:含噻唑/苯并噻唑环的新型二硫代氨基甲酸酯衍生物的合成及抗菌活性评价
标题:含噻唑/苯并噻唑环的新型二硫代氨基甲酸酯衍生物的合成及抗菌活性评价
摘要:图形摘要摘要 2-(取代苯基)-2-氧乙基4-(嘧啶-2-基)哌嗪-1-碳二硫代(A1-A24)衍生物和2-(4-取代的噻唑-2-基氨基)-的合成2-氧乙基4-(嘧啶-2-基)哌嗪-1-碳二硫代(B1-B14)衍生物从4-(2-嘧啶基)哌嗪二硫代氨基甲酸酯的钾盐开始进行.所得化合物的结构通过1H NMR,13C NMR,Ms谱数据和元素分析阐明.使用微量稀释技术测试了 38 种新合成化合物对 12 种微生物菌株的抗菌活性.化合物 2-(4-Ethoxycarbonylthiazol-2-Ylamino)-2-Oxoethyl 4-(Pyrimidin-2-yl)Piperazin-1-Carbodithiodate (B12),2-(3-Fluorophenyl)-2-Oxoethyl 4-(Pyrimidin-2-yl)Piperazin-1-Carbodithiodate (A18)
Doi:10.1080/10426507.2016.1150277

专利信息

专利号:US-6136984-A
优先权日:1996-04-22
标 题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest is disclosed. The thiophenes are prepared by acylation of a substrate-bound primary or secondary amine with cyanoacetic acid and reaction of the resulting cyanoacetamide with an isothiocyanate in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegier-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-7094928-B2
优先权日:2002-08-21
标题 :Process for the synthesis of (±) 2-Amino-N-[2,(2,5-dimethoxy phenyl)-2-hydroxyethyl] acetamide monohydrochloride
发明人：SUBRAMANIAN RAJARAM SANKARA; SATAGOPAN VENKATANATHAN; SRINIVASAN RAJAGOPALAN
权利人:SANMAR SPECIALTY CHEMICALS LTD
摘要:This invention relates to an improved process for synthesizing (±)-2-Amino-N-[2-(2,5-dimethoxyphenyl]-2-hydroxyethyl acetamide monohydrochloride in good yield and in a cost effective manner from 1-(2,5-dimethoxyphenyl)-2-bromoethanone by reacting the same with hexamine in the presence of novel solvent system comprising Tetrahydrofuran and water. The resulting aminoethanone is acylated with haloacetylchloride and sodium acetate in acetone-water solvent system. This product is reduced selectively first with sodium borohydride and subsequently with stannous chloride. This product is converted in situ to the corresponding hydrochloride salt immediately after reduction on its own.

专利号:US-8906915-B2
优先权日:2009-12-17
标 题:Compounds, compositions, and methods for controlling biofilms
发明人：DE KEERSMAECKER SIGRID; DE VOS DIRK; ERMOLATEV DENIS; STEENACKERS HANS; VAN DER EYCKEN ERIK; VANDERLEYDEN JOZEF; SAVALIYA BHARAT S
权利人:DE KEERSMAECKER SIGRID; DE VOS DIRK; ERMOLATEV DENIS; STEENACKERS HANS; VAN DER EYCKEN ERIK; VANDERLEYDEN JOZEF; SAVALIYA BHARAT S; UNIV LEUVEN KATH
摘要:The invention relates to substituted 2-aminoimidazoles and their imidazo[1,2-a]pyrimidinium salts precursors being active against biofilm formation. The invention also relates to imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent, and to substituted 2-aminoimidazoles wherein the amino group bears a terminal heterocyclic group such as a triazolyl group which are formed through azide-alkyne Huisgen cycloaddition starting from said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to a class of N-(azidoalkyl)pyrimidin-2-amines useful as starting materials for the synthesis of said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to antimicrobial compositions that include a microbial biofilm formation inhibiting amount of such substituted 2-aminoimidazoles or imidazo[1,2-a]pyrimidinium salts in combination with excipients. Methods for inhibiting or controlling microbial biofilm formation in a plant, a body part of a human or an animal, or a surface with which a human or an animal may come into contact are also disclosed.

专利号:CA-2459175-A1
优先权日:2002-08-21
标 题:An improved process for the synthesis of (±)2-amino-n-(2,(2,5-dimethoxyphenyl)-2-hydroxyethyl) acetamide monohydrochloride

专利号:WO-9740034-A1
优先权日:1996-04-22
标题:Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes

专利号:EP-1021435-A1
优先权日:1996-04-22
标题:Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes