CAS: 109-84-2; 2-Hydrazinoethanol

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CAS号141-43-5 2-氨基乙醇 | CAS号75-21-8 环氧乙烷 | CAS号107-07-3 2-氯乙醇 | CAS号1517-05-1 2-叠氮基乙醇 | CAS号67-56-1 甲醇 | CAS号7803-57-8 水合肼 | CAS号1049678-66-1 2-(3-(吡啶-2-基)-1... | CAS号1049678-82-1 2-(5-(pyridin-2... | CAS号58046-49-4 5-氨基-1-(2-羟乙基)吡... | CAS号473921-12-9 3-氰基-5-[[3,5-二乙... | CAS号2488-95-1 β-羟乙基乙二胺 | CAS号13529-51-6 2,2'-hydrazonob... | CAS号28127-20-0 2-Propanone,2-(... | CAS号25431-80-5 2-Butanone,2-(2... | CAS号80-65-9 3-氨基-2-恶唑烷酮 | CAS号5346-53-2 1-羟乙基-4-氰基-5-氨基吡唑

环氧乙烷置于sodium Hydroxide,肼体系中,化学反应生成2-肼基乙醇
参考文献:2-氯乙醇对肼和2-羟乙基肼烷基化的动力学研究:介质中强碱的影响
标题:2-氯乙醇对肼和2-羟乙基肼烷基化的动力学研究:介质中强碱的影响
摘要:为了优化收率,在有或没有氢氧化钠的情况下,进行了有关由2-氯乙醇(cletoh)将n 2 H 4烷基化而得到的2-羟乙基肼(heh)合成反应动力学的研究.在这两种情况下,Heh形成的主要反应是heh烷基化(或n 2 H 4的二烷基化)的连续平行反应,导致形成两种异构体:1,1-二(羟乙基)肼和1,2-二(羟乙基)肼 在这项研究中,肼和羟烷基肼的烷基化反应遵循s N2个反应直接由cletoh引发,或在强碱存在下由环氧乙烷(一种中间化合物)间接引发.通过气相色谱和气相色谱-质谱联用(gc-Ms)定量heh和cletoh,在稀释的介质中研究了动力学.建立了每个反应的活化参数以及培养基中存在的强碱对反应机理的影响.全局数学处理适用于每个替代方法.它允许根据试剂浓度和温度对反应进行建模.在通过cletoh直接烷基化的情况下,模拟建立了半分批和分批合成和在实验对于浓缩的介质(证实的1.0M<=[cletoh]
Doi:10.1002/kin.20409

专利信息

专利号:US-5618944-A
优先权日:1993-05-05
标题:Method for the synthesis of anthrapyrazolones
发明人：ZHANG LIN-HUA; AUERBACH JOSEPH
权利人:DU PONT MERCK PHARMA
摘要:This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphenyl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.

专利号:US-9950988-B2
优先权日:2012-12-26
标题:Method for the synthesis of alpha/alpha-prime-alcoxylated glycerol linear carbonic esters
发明人：LEISING FRéDéRIC; MOULOUNGUI ZéPHIRIN
权利人:CHRYSO; INST NAT POLYTECHNIQUE TOULOUSE; INST NAT DE LA RECH AGRONOMIQUE INRA
摘要:A method for the synthesis of α/α′-alcoxylated glycerol linear carbonic esters, wherein the following are brought into contact at a reaction temperature lower than 220° C.: a quantity of at least one precursor selected from the group consisting of α/α′-alcoxylated glycerol cyclo-carbonates; a quantity of at least one catalyst selected from the group consisting of metal oxides, Lewis acids, organometallic catalysts and mineral bases; and a quantity of at least one organic primer. A composition containing at least one novel α/α′-alkoxylated glycerol linear carbonic ester.

专利号:US-8785656-B2
优先权日:2012-02-16
标 题:Telescoping synthesis of 5-amino-4-nitroso-1-alkyl-1H-pyrazole salt
发明人：GEIBEL WOLFRAM; WEBER INGO; OSAN ARMIN; SPECKBACHER MARKUS
权利人:PROCTER & GAMBLE
摘要:A telescoping synthesis of 5-amino-4-nitroso-1-alkyl-1H-pyrazole salt derivatives of formula (I), the compound (I) itself, and its use as an intermediate in the fabrication of 1-alkyl-4,5-diaminopyrazole salts of general formula (IX). The compounds of formula (IX) can be used as precursor dyes in oxidative hair dye compositions. n n n n n n n n n n R is a mono- or poly-substituted or unsubstituted, straight or branched, saturated or mono- or poly-unsaturated, alkyl group. HZ and HZ′ are organic or mineral acids.

专利号:US-7390929-B2
优先权日:2003-12-17
标题 :Method for the continuous synthesis of monoalkyl-hydrazines with a functionalized alkyl group
发明人：DELALU HENRI; COLAS-DURICHE CECILE; BERTHET JACQUES; LEURENT PHILIPPE
权利人:ISOCHEM SA; CENTRE NAT RECH SCIENT; UNIV CLAUDE BERNARD LYON
摘要:The invention relates to a method for the continuous synthesis of monoalkyl-hydrazines with a functionalized alkyl group. The inventive method is characterized in that it comprises a step consisting in demixing a solution containing the synthesized monoalkyl-hydrazine, by reacting an anhydrous amine with monochloramine, in an organic phase and an aqueous phase with the addition of anhydrous sodium hydroxide. The invention can be used to obtain perfect selectivity in relation to monoalkyl-hydrazine without the presence of the di- and tri-substituted forms thereof. According to the invention, the staffing amine which has not reacted is collected and reused directly without any additional treatment.

专利号:US-9481840-B2
优先权日:2009-04-13
标题 :Hydroxyethylhydrazinium nitrate-acetone formulations and methods of making hydroxyethylhydrazinium nitrate-acetone formulations
发明人：SMITH JR JAMES E; OGDEN GREGORY E; BROWN CLINTON J; FRISBY PAUL M; TORABZADEH SAHAR A
权利人:SMITH JR JAMES E; OGDEN GREGORY E; BROWN CLINTON J; FRISBY PAUL M; TORABZADEH SAHAR A; UNIV OF ALABAMA IN HUNTSVILLE; OGDEN ENG & ASS LLC
摘要:Embodiments of the present disclosure include one-step synthesis to prepare a hypergolic green Fuel (HGF) propellant from 2-Hydroxyethylhydrazine (HEH) via a “one-step synthesis methodâ€?. In addition, embodiments of the present disclosure include fully nitrated HGF and partially nitrated HGF and formulations containing Hydroxyethylhydrazinium Nitrate (HEHN) and acetone, where the HEHN is produced independently.

专利号:US-6906046-B2
优先权日:2000-12-22
标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes
发明人：JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY
权利人:CELLTECH R & D INC
摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.