专利号:WO-2022228297-A1 优先权日:2021-04-26 标 题:Enzymatic preparation technique for acyl/aroyl coenzyme a 发明人:ZHU PING; ZHANG BOYONG; WANG HAO; GONG TING; CHEN TIANJIAO; CHEN JINGJING; YANG JINLING 权利人:INST OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCICENCES 摘要:Provided are a method for large-scale preparation of acyl/aroyl coenzyme A by an enzymatic method, i.e., using an acyltransferase to transfer acyl/aroyl from a cheap acyl/aroyl donor onto acyl/aroyl receptor coenzyme A, thereby achieving large-scale synthesis of acyl/aroyl coenzyme A, and a use of the method in the preparation of acyl/aroyl coenzyme A.
专利号:US-2019054057-A1 优先权日:2016-03-08 标题 :Immune boosting dietary compounds for disease control and prevention 发明人:ZHANG GUOLONG 权利人:THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIV OFFICE OF INTELLECTUAL PROPERTY MANAGEMENT 摘要:Provided herein are small-molecule compounds and combinations thereof that enhance the synthesis of animal endogenous genus host defense peptides, which display potent antimicrobial and immunomodulatory activities. They thus represent alternatives to antibiotics for disease control and prevention for use in animals and humans. Examples of the small molecule compounds include histone deacetylase inhibitors, mono- and disaccharide sugars, cyclic adenosine monophosphate (cAMP) signaling agonists, and cyclooxygenase -2 (COX-2) inhibitors. Synergistic combinations include short-chain fatty acids, their chemical analogs or histone deacetylase inhibitors with other fatty acids, sugars, cAMP signaling agonists, and/or COX-2 inhibitors.
专利号:US-6835841-B2 优先权日:2002-09-13 标 题:Asymmetric catalytic hydrogenation process for preparation of chiral cyclic β-aminoesters 发明人:DEERBERG JOERG; MCLEOD DOUGLAS D; YUE TAI-YUEN 权利人:BRISTOL MYERS SQUIBB CO 摘要:A novel process for the asymmetric synthesis of substituted cyclic beta-amino-carboxylates of the type shown in the specification from appropriate beta-enamino-ester starting materials is described. These compounds are useful as intermediates for MMP and TACE inhibitors.
专利号:US-6525096-B1 优先权日:1990-11-27 标题:GABA and L-glutamic acid analogs for antiseizure treatment 发明人:SILVERMAN RICHARD B; ANDRUSZKIEWICZ RYSZARD; YUEN PO-WAI 权利人:UNIV NORTHWESTERN; WARNER LAMBERT CO 摘要:A compound of the formulawherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
专利号:US-4021457-A 优先权日:1975-11-18 标 题 :Intermediates for polycyclic quinonoid antibiotics 发明人:KENDE ANDREW S; MILLS JOHN E; TSAY YUH-GENG 权利人:RESEARCH CORP 摘要:There is provided a novel method of synthesizing certain tetracyclic quinones. In particular, there is provided a novel route to the synthesis of certain analogs of (+)-7-deoxydaunomycinone which includes the provision of novel tri- and tetracyclic quinone intermediates. The products of the synthetic route provided herein may be converted into compounds of known anti-neoplastic activity.
专利号:EP-3002290-A2 优先权日:2007-06-19 标 题 :Synthesis of deoxycholic acid (dca)
摘要:Food and Cosmetics Toxicology., 2(327), 1964 摘要:de Figueiredo, R. M., Science of Synthesis: Knowledge Updates, (2024) 2, 261. 摘要:Liao, L.; Zhang, Y.; Yu, J.-S., Science of Synthesis: Knowledge Updates, (2024) 1, 207. 摘要:Xiao, D.; Du, Y., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) . 参考文献:10.1007/s10886-019-01085-1 摘要:Keesey IW, Jiang N, Weißflog J, Winz R, Svatoš A, Wang C, Hansson BS, Knaden M. Plant-Based Natural Product Chemistry for Integrated Pest Management of Drosophila suzukii. Journal of Chemical Ecology. 2019 Jul 01;45(7):626–37. doi: 10.1007/s10886-019-01085-1.