CAS: 10289-45-9; 4-Propyl-1,1'-Biphenyl

相似化合物

37909-95-8 360768-57-6 7116-96-3

上下游产品

propan-1-ol biphenyl 1-biphenyl-4-yl-propan-1-one isopropyl alcohol 1-(4'-propyl-[1,1'-biphenyl]-4-yl)ethanone 4-cyano-4'-n-propylbiphenyl 4-n-propyl-4'-bromobiphenyl 1-(4-biphenylyl)-2-propanone

📜1-([1,1'-Biphenyl]-4-yl)Propan-1-Ol置于palladium On Activated Charcoal,氢气,对甲苯磺酸体系中,用 甲苯 用作溶剂,化学反应 21.0H,反应生成4-正丙基联苯
参考文献:一种4-溴-4'-丙基联苯的合成工艺
标题:一种4-溴-4'-丙基联苯的合成工艺
摘要:本发明公开了一种4‑溴‑4'‑丙基联苯的合成工艺,涉及医药合成技术领域,解决了现有工艺反应条件苛刻,总收率低的问题.本发明避免了黄鸣龙反应还原需要的超高温反应条件或者卤锂交换反应需要的超低温反应条件,不使用致癌化合物碘丙烷,反应条件温和,合成工艺条件更容易控制,易于操作,后处理简单;本发明的合成工艺化学反应原子经济性高,相比于现有工艺中的20‑30%的总收率,本工艺总收率达57%,显著提高产品收率;本发明使用廉价易得的工业化学品联苯做起始原料,降低成本.

专利信息

专利号:WO-9955664-A1
优先权日:1998-04-24
标 题 :Preparation of carbocyclic compounds
发明人：BECKER MARK W; CHAPMAN HARLAN H; KELLY DAPHNE E; KENT KENNETH M; LEW WILLARD; LOUIE MICHAEL S; MCGEE LAWRENCE R; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; SCHULTZE LISA M; YU RICHARD H; ZHANG LIJUN
权利人:GILEAD SCIENCES INC; BECKER MARK W; CHAPMAN HARLAN H; KELLY DAPHNE E; KENT KENNETH M; LEW WILLARD; LOUIE MICHAEL S; MCGEE LAWRENCE R; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; SCHULTZE LISA M; YU RICHARD H; ZHANG LIJUN
摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

专利号:US-10385004-B2
优先权日:2015-02-13
标 题:Process and intermediates for the preparation of NEP inhibitors
发明人：MARTIN BENJAMIN; MANDRELLI FRANCESCA; VENTURONI FRANCESCO
权利人:NOVARTIS AG
摘要:The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

专利号:US-7354923-B2
优先权日:2001-08-10
标 题 :Piperazine melanocortin-specific compounds
发明人：SHARMA SHUBH D; SHI YI-QUN; WU ZHIJUN; RAJPUROHIT RAMESH
权利人:PALATIN TECHNOLOGIES INC
摘要:Melanocortin receptor-specific piperazine or ketopiperazine compounds having the structure: n nand stereoisomer and pharmaceutically acceptable salts thereof, where X is CH 2 or Câ•?O, R 1 , R 2 , and R 3 are as described in the specification, preferably where R 3 is a D-amino acid with at least one substituted or unsubstituted phenyl or naphthyl aromatic ring, and where R 3 optionally further includes an amine capping group, a second amino acid residue or a second amino acid residue with an amine capping group, which compounds are agonists, antagonists or mixed agonists and antagonists at one or more melanocortin receptors, and having utility in the treatment of melanocortin receptor-related disorders and conditions. Methods of synthesis of compounds of structure (I), pharmaceutical compositions containing a compound of structure (I) and methods relating to the use thereof are also disclosed.

专利号:US-9879037-B2
优先权日:2012-03-30
标 题 :Fluorine-containing phosphate ester-amide, and flame retardant resin, flame retardant liquid and flame retardant solvent for organic synthesis containing same
发明人：MIMURA HIDEYUKI; FUJITA HIROAKI; EGUCHI HISAO
权利人:TOSOH F-TECH INC
摘要:[Problem] To provide a fluorine-containing phosphate ester-amide which has high flame retardancy such as exhibiting flame retardant effects at a small quantity of addition, and sufficient hydrolysis resistance. n [Solution] A fluorine-containing phosphate ester-amide represented by general formula (1). (In the formula, R1 and R2 are the same or different and represent a branched or linear alkyl group having 1 to 20 carbon atoms in which at least one carbon bonded to a nitrogen atom is a secondary or tertiary carbon, wherein R1 and R2 may have a substituent group selected from the group consisting of an alkoxy group, a hydroxy group, an amino group, a methyl amino group, an ethyl amino group, a dimethyl amino group, diethyl amino group and a fluorine atom. In addition, R1 and R2 may be bonded together to form a five- to eight-membered cyclic structure. X and Y are the same or different and represent a hydrogen atom or a fluorine atom, and n and m represent an integer of 1 to 6.)

专利号:WO-9804543-A1
优先权日:1996-07-29
标 题:Improved process for the synthesis of protected esters of (s)-3,4-dihydroxybutyric acid

专利号:EP-3704130-A1
优先权日:2017-11-01
标 题 :Synthesis of boronate ester derivatives and uses thereof