CAS: 99189-60-3; 2-[1-(2-Amino-2-Oxoethyl)Cyclohexyl]Acetic Acid

相似化合物

4355-11-7 60142-96-3 99189-60-3

上下游产品

CAS号1130-32-1 3,3-环戊烷戊二酰亚胺 | CAS号1010-26-0 1,1-环己基二乙酸酐 | CAS号64744-50-9 4,4-五亚甲基-2-吡咯烷酮 | CAS号60142-96-3 加巴喷丁

Spiro[cyclohexane-1,9'-(3,7-Diazabicycle-[3.3.1]Nonane)]-2',4',6',8'-Tetraone置于水,Sodium Hydroxide体系中,化学反应 18.0H,以80.8%的收率获得产物1,1-环己基二乙酸单酰胺
参考文献:Process For The Preparation Of Gabapentin
标题:Process For The Preparation Of Gabapentin
摘要:本发明涉及一种改进的加巴喷丁制备工艺.该工艺还涉及一种新的1,1-环己烷二乙酸单酰胺(cdma)制备工艺,该工艺是制备加巴喷丁的关键中间体.

专利信息

专利号:US-2008103334-A1
优先权日:2006-10-26
标 题:Process For Synthesis Of Gabapentin
发明人：KUMAR ASHOK; SOUDAGAR SATISH RAJANIKANT; NIJASURE AVINASH MANOHAR; PANDA NALINAKSHYA BALARAM; GAUTAM PRASHANT; THAKUR GAJENDRASINGH RAMSINGH
权利人:IPCA LAB LTD
摘要:A process for preparation of gabapentin comprising a step of obtaining 1,1-cyclohexane diacetic acid monoamide from 1,1-cyclohexane diacetic acid anhydride, wherein said reaction is characterized by the use of ammonia precursor or pre-generated ammonia-isopropanol solution. The invention further discloses preparation of gabapentin and isolation of gabapentin in polymorphic Form II with high yield and purity.

专利号:US-7759517-B2
优先权日:2004-06-24
标 题:Process for the preparation of gabapentin
发明人：VILLA MARCO; PAIOCCHI MAURIZIO; ARRIGHI KATIUSCIA; CORCELLA FRANCESCO; CANNATA VINCENZO; SORIATO GIORGIO; VERZINI MASSIMO
权利人:ZACH SYSTEM SPA
摘要:The present invention relates to a process for the preparation of gabapentin and, more in particular, to a method of synthesis of 1,1-cyclohexane acetic acid monoamide, an intermediate used in the preparation of gabapentin, comprising the basic hydrolysis reaction of α, -diaminocarbonyl-β,β-pentamethylene glutarimide.

专利号:US-7381823-B2
优先权日:2004-03-17
标 题 :Process for preparing cyclohexanediacetic acid monoamide
发明人：DANIELI BRUNO; DELOGU PIETRO; ROSA SABRINA DE; FUGAZZA LORENZA
权利人:SERICHIM S R L
摘要:A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitable malonic acid ester. A new intermediate (5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid ester) is obtained which is convertible, under mild reaction conditions, into cyclohexanediacetic acid monoamide.