CAS: 99-36-5; Methyl 3-Methylbenzoate

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CAS号67-56-1 甲醇 | CAS号620-23-5 间甲基苯甲醛 | CAS号201230-82-2 carbon monoxide | CAS号591-17-3 3-溴甲苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号99-04-7 间甲基苯甲酸 | CAS号587-03-1 3-甲基苄醇 | CAS号625-95-6 3-甲碘苯 | CAS号1711-06-4 间甲基苯甲酰氯 | CAS号134039-35-3 methyl 5-[N,N-d... | CAS号105576-60-1 4-amino-3-(3-me... | CAS号5471-82-9 3-甲基-2-硝基苯甲酸甲酯 | CAS号20587-30-8 2-硝基-5-甲基苯甲酸甲酯 | CAS号587-03-1 3-甲基苄醇 | CAS号22717-57-3 5-甲基水杨酸甲酯 | CAS号4670-56-8 4-甲基水杨酸甲酯 | CAS号142031-67-2 4-溴-3-(溴甲基)苯甲酸甲酯 | CAS号929626-17-5 3-甲基-5-甲氧基羰基苯基硼... | CAS号216529-53-2 2-吡啶-4-基-1-间甲苯乙酮 | CAS号115-10-6 二甲醚

📜N-Methoxy-3-Methylbenzamide置于间氯过氧苯甲酸,Copper(Ll) Bromide体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 3.0H,以70%的收率获得产物3-甲基苯甲酸甲酯
参考文献:铜介导的n-烷氧基酰胺的氧化均偶联和重排:制备芳族酯的有效方法
标题:铜介导的n-烷氧基酰胺的氧化均偶联和重排:制备芳族酯的有效方法
摘要:N-烷氧基酰胺通过铜催化的氧化均偶联和鹭重排以中等至令人满意的产率成功地转化为其相应的酯.该方法可耐受多种官能团,并允许合成传统酰化化学方法不易获得的位阻酯产物.已经初步提出了自由基介导的途径用于氧化过程.
DOI:10.1016/j.Tetlet.2015.06.023

专利信息

专利号:WO-2013144924-A1
优先权日:2012-03-29
标 题:An improved process for the synthesis of strobilurin fungicides viz trifloxystrobin and kresoxim-methyl
发明人：KAMARAJ PASUMPON; SATAM VIJAY SHRIKANT; AJJANNA MAHALINGAPPA SRIDHARA; NANDI TAPASKUMAR; BOBADE ANNA; SHINDE RAVINDRA; NAIK PARAG; MOHITE DHANAJI; KADAM SUBHASH; HINDUPUR RAMA MOHAN; PATI HARI NARAYAN; MANE AVINASH; VADIRAJ SUPHALA GOPINATH; VENKATESH PRABHU MOODBIDRI
权利人:RALLIS INDIA LTD
摘要:The present invention relates to an improved process for the synthesis of E -isomer of compound of formula (5). It further relates to the conversion of formula (5), wherein R is H, to Intermediate (I) and subsequently to substantially pure Trifloxystrobin, compound of formula (I) in good yield.

专利号:EP-0946499-B1
优先权日:1996-11-22
标 题 :N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：WU JING; TUNG JAY S; NISSEN JEFFREY S; MABRY THOMAS E; LATIMER LEE H; EID CLARK NORMAN; AUDIA JAMES E
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions. Said compounds are represented by formula (I), wherein R<1> is selected from the group consisting of: a) alkyl, alkenyl, alkaryl, alkcycloalkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl and heterocyclic; b) a substituted phenyl group of formula (II), wherein R is alkylene of from 1 to 8 carbon atoms, m is an integer equal to 0 or 1, and c) 1- or 2-naphthyl substituted at the 5, 6, 7 and/or 8 positions, R<2> is selected from the group consisting of hydrogen, alkyl of from 1 to 4 carbon atoms, alkylalkoxy of from 1 to 4 carbon atoms, alkylthioalkoxy of from 1 to 4 carbon atoms; and R<3> and R<3'> are independently selected from the group consisting of: (a) hydrogen, (b) alkyl, (c) -(R<7>)n(W)p, wherein R<7> is an alkylene group, W is selected from the group consisting of (i) formula (A); (ii) heteroaryl; and (iii) N-heterocyclic, and n is an integer equal to 0 or 1, and p is an integer equal to 1 to 3; (d) -CH( phi )CH2C(O)O-Q where Q is selected from the group consisting of alkyl, aryl, heteroaryl and heterocyclic; X' is hydrogen, hydroxy or fluoro; X'' is hydrogen, hydroxy or fluoro, or X' and X'' together form an oxo group, Z is selected from the group consisting of a bond covalently linking R<1> to -CX'X''-, oxygen and sulfur.

专利号:US-6262302-B1
优先权日:1996-11-22
标题:N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：WU JING; TUNG JAY S; NISSEN JEFFREY S; MABRY THOMAS E; LATIMER LEE H; EID CLARK N; AUDIA JAMES E
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-4719053-A
优先权日:1980-08-01
标题 :Beta-chloroethylsulfonylmethyl-benzoic halides as intermediates
发明人：SCHLAEFER LUDWIG; HAEHNLE REINHARD
权利人:HOECHST AG
摘要:New beta -chloroethylsuflonylmethyl-benzoic acid halides which can serve as fibre-reactive anchors for thesynthesis of novel organic, water-soluble compounds, preferably dyestuffs, having fibre-reactive and fibre-finishing properties, such as preferably dyestuff properties, and containing, as a fibre-reactive group, one or two beta -chloroethylsufonylmethylbenzoic acid amide groups. For the synthesis of these novel fibre-finishing compounds, said new beta -chloroethylsulfonylmethyl-benzoic acid halide compounds are reacted with an organic, water-soluble compound having fibre-finishing properties and continuing one or two amino groups. Also precursors of the fibre-finishing, fibre-reactive compounds, containing said beta -chloroethylsulfonylmethyl-benzxoic acid amid grouping, can be employed for their synthesis. The novel fibre-finishing compounds can be applied onto suitable fibre materials, such as especially cellulose fibre material and natural or synthetic polyamide fibre materials, and fixed on these fibre materials in a manner similar to application and fixation methods usual in the technique for fibre-reactive compounds. The fibre-finished material, such as dyed material, shows very good wet fastnesses.

专利号:US-2010035867-A1
优先权日:2006-07-11
标 题 :Inhibitors of Cyclic Nucleotide Synthesis and Their Use for Therapy of Various Diseases
发明人：GUERRANT RICHARD L; KOTS ALEXANDER Y; MURAD FERID; CHOI BYUNG-KWON
权利人:GUERRANT RICHARD L; KOTS ALEXANDER Y; MURAD FERID; CHOI BYUNG-KWON
摘要:We disclose a method of inhibiting activity of adenylyl cyclase or guanylyl cyclase in a mammal by administering to the mammal an amount of a composition effective to inhibit the activity, wherein the composition contains at least one compound selected from the group consisting of structural formulae (Ia) and (Ib) and salts thereof, wherein R1 is —H or has the structure —C(â•?O)R8; R2 is â•?O or has the structure —OC(â•?O)R9; and R3, R4, R5, R6, and R7 are each independently selected from the group consisting of —H, —NO 2 , formula (I), -halogen, —OC(â•?O)R9, —OR9, —OH, —R8OH, —CH 3 , —OC(â•?O)CH 2 Ph, formulae (II), (III), (IV), —OPh, —CF 3 , —R8, —C(â•?O)OR9, -Ph, —R8Ph, formulae (V), (VI), (VII), (VIII), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), (XVII), (XVIII), (XIX), (XX), and (XXI), wherein each R8 is independently a linear or branched hydrocarbon group having from 1 to 4 carbon atoms and each R9 is independently a hydrocarbon group having from 1 to 2 carbon atoms. Administering the composition can be used to treat a disease in a mammal mediated by activity of adenylyl cyclase or guanylyl cyclase and effected by a toxin produced by a pathogenic organism or to reduce cyclic AMP or cyclic GMP levels in a mammal in need of reduction thereof. The composition can also be administered to mammalian cells in vitro. The above methods of inhibiting activity of adenylyl cyclase or guanylyl cyclase and treating diseases via such inhibition can be effective without prolonged treatment, have reversible effects, have low or no toxicity, are highly potent, are unlikely to have side effects, do not act on purinergic recptors, or can negate pathogenic toxins independently of whether the pathogenic organism survives.

专利号:US-8981092-B2
优先权日:2008-09-19
标题 :Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity
发明人：MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO
权利人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 4,7-disubstituted derivatives of 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one compounds, n nor pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.