CAS: 910867-11-7; (4E)-5-{4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulfonylamino)Pyrimidin-5-Yl}-(3S)-3-Hydroxy-4-Pentenoic Acid

英文名称(4E)-5-{4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulfonylamino)Pyrimidin-5-Yl}-(3S)-3-Hydroxy-4-Pentenoic Acid
中文名称瑞舒伐他汀取代羟基戊烯酸
CAS编号910867-11-7
分子式:C20H24FN3O5S分子量:437.49
产品CID: 1945626
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: LWBSCJQFMOAAHH-BOLDSZDNSA-N
1S/C20H24FN3O5S/c1-12(2)18-16(10-9-15(25)11-17(26)27)19(13-5-7-14(21)8-6-13)23-20(22-18)24(3)30(4,28)29/h5-10,12,15,25H,11H2,1-4H3,(H,26,27)/b10-9+/t15-/m1/s1
计算化学: 氢键受体数9.0氢键供体数2.0可旋转键数8.0

MSDS等安全信息

上下游产品

(4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl}-(3S)-3-hydroxy-4-pentenoic acid R-(+)-α-methylbenzylamine salt(3S)-5-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3-hydroxy-(4E)pentenoic acid methyl ester (4E)-5-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-(3S)-3-(O-tert-butyldimethylsilyl)-4-pentenoic acid methyl (6E)-7-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}(5S)-5-hydroxy-3-oxo-6-heptenoate

合成工艺路线路线简述

📜(4E)-5-{4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulfonylamino)Pyrimidin-5-Yl}-(3S)-3-Hydroxy-4-Pentenoic Acid R-(+)-α-Methylbenzylamine Salt置于盐酸体系中,用二氯甲烷,水作为反应溶剂,以97%的收率获得产物瑞舒伐他汀取代羟基戊烯酸
参考文献:Process For Preparing Rosuvastatin Calcium
标题:Process For Preparing Rosuvastatin Calcium
摘要:本发明涉及一种改进的制备化学式i的罗伴他汀钙的方法.