CAS: 85331-33-5; 3,5-Dichloropicolinonitrile

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81719-53-1 471909-65-6 38180-46-0

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2,3,5-三氯吡啶 以 N,N-二甲基乙酰胺,醋酸异丙酯 作为反应溶剂,化学反应生成 3,5-二氯-2-氰基吡啶
参考文献: Manufacturing Process For 3,5-Dichloropicolinonitrile For Synthesis Of Vadadustat[fr] Processus De Fabrication De 3,5-Dichloropicolinonitrile Pour La Synthèse De Vadadustat
标题: Manufacturing Process For 3,5-Dichloropicolinonitrile For Synthesis Of Vadadustat[fr] Processus De Fabrication De 3,5-Dichloropicolinonitrile Pour La Synthèse De Vadadustat
摘要:本文揭示了制备vadadustat或其药学上可接受的盐的方法和过程,以及用于合成vadadustat的中间体(例如,化合物式(i),(i-F),(II)或(iv)或其药学上可接受的盐).

专利信息

专利号:US-2023286918-A1
优先权日:2020-07-02
标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat
发明人：JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER
权利人:AKEBIA THERAPEUTICS INC
摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.

专利号:US-12269802-B2
优先权日:2018-05-09
标题:Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl] amino] acetic acid
发明人：GORIN BORIS I; LANTHIER CHRISTOPHER M; LUONG ANNE BUU CHAU; COPP JAMES DENSMORE; GONZALEZ JAVIER; JAUTZE SASCHA; KRAUS ERICH; O'CONNOR ALAN
权利人:AKEBIA THERAPEUTICS INC
摘要:Disclosed herein are methods and processes of preparing vadadustat and pharmaceutically acceptable salts thereof, and intermediates of formula (I) and their salts useful for the synthesis of vadadustat.

专利号:WO-2022006427-A1
优先权日:2020-07-02
标题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat

专利号:US-9957277-B2
优先权日:2015-11-25
标题 :eIF4A-inhibiting compounds and methods related thereto
发明人：ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; TRAN CHINH VIET; PACKARD Garrick Kenneth; XIANG ALAN X; NILEWSKI CHRISTIAN; MICHELS THEO
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds X, Y, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b and R 5 are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.