CAS: 75-57-0; Tetramethylammonium Chloride

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64-20-0 75-58-1 1941-24-8

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专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:WO-2021038581-A1
优先权日:2019-08-30
标题 :A one step synthesis of 2-substituted benzo[b]thiophenes
发明人：SEKAR GOVINDASAMY; POONGUZHALI ELAMVAZHUTHI
权利人:INDIAN INST TECH MADRAS
摘要:The invention pertains to a one step synthesis of 2-substituted benzo[ b ]thiophene of general formula wherein the synthesis of 2-substituted benzo[ b ]thiophenes is by reacting the starting materials substituted or unsubstituted 2-halogenobenzaldehyde and substituted or unsubstituted acetyl/phenacyl bromide with a catalyst, a sulphur source and phase transfer catalyst in an aqueous medium with atmospheric air and at temperature in the range of 25°C-30°C.

专利号:US-2008103312-A1
优先权日:2006-08-29
标 题:Processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole
发明人：KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D
权利人:KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D
摘要:Provided are processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole, an intermediate useful in the synthesis of irbesartan.

专利号:US-4431828-A
优先权日:1982-11-10
标题 :Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil
发明人：CUE JR BERKELEY W; HAMMEN PHILIP D; MASSETT STEPHEN S
权利人:PFIZER
摘要:6-Fluoro-4-chromanone, a sorbinil intermediate, is regenerated from enantiomeric and mixtures of enantiomeric and racemic compounds obtained as major by-products in the synthesis of sorbinil. The regenerated intermediate is useful in the synthesis of additional sorbinil.

专利号:US-6339131-B1
优先权日:1999-12-06
标题 :Synthesis of poly (arylene ether)-poly(organosiloxane) copolymers
发明人：CELLA JAMES A; LISKA JURAJ; ULERY VICTORIA L; YEAGER GARY W; NYE SUSAN ADAMS; GUO HUA; SINGH NAVJOT
权利人:GEN ELECTRIC
摘要:A method comprising n (a) synthesis of a poly(arylene ether) having the structure (1) n wherein m is an integer having an average value in the range from about 3 to about 300; n (b) solution functionalization of polymer (1) to form functionalized poly(arylene ether) having the structure (2) n wherein X is a reactive functional group selected from the group consisting of anhydride, hydroxyl, epoxy, carboxyl, —R 1 OH, R 1 CO 2 R 2 , —R 1 CH 2 â•?CH 2 , or vinyl, wherein R 1 is a primary or secondary divalent alkyl or haloalky group having from 1 to 20 carbons, or an aryl group and R 2 is a primary or secondary alkyl group having from 1 to 10 carbons; and Q 4 is hydrogen, X, or a mixture thereof; n (c) reaction of functionalized poly(arylene ether) (2) with a poly(organosiloxane) having structure (3): n wherein x is zero or one and Y is a functional group reactive with X, selected from the group consisting of —OH, —CH 2 â•?CH 2 , epoxy, amino, carboxy, —C(O)CH 2 OH, or hydrogen, to form a poly(arylene ether)-poly(siloxane) copolymer, wherein the functionalization is in solution, and copolymer synthesis and isolation are effected by first solution nd then melt copolymerization.

专利号:US-2023286918-A1
优先权日:2020-07-02
标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat
发明人：JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER
权利人:AKEBIA THERAPEUTICS INC
摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.