CAS: 70563-58-5; Herbimycin

上下游产品

CAS号115929-62-9 3-溴-2,5-二甲氧基苯胺

📜(4R,6S)-7-Tert-Butyldiphenylsilyloxy-6-Methylhept-1-Ol-4-Ol置于rucl2(1,3-Dimesityl-Imidazolidin-2-yl)(Pcy3)(=chph),2,6-二甲基吡啶,甲醇,4-二甲氨基吡啶,氟化铵,Lithium Hydroxide,Sodium Periodate,四氧化锇,四(三苯基膦)钯,正丁基锂,1,3-二甲基巴比妥酸,Ammonium Cerium(Iv) Nitrate,[1,3-Mes2-(N2C3H5)]Cl2(Pcy3)Ru=chph,4 A Molecular Sieve,三氟化硼乙醚,N-Tritylprop-2-En-1-Amine,四丁基氟化铵,水,仲丁基锂,双(2-氧代-3-恶唑烷基)次磷酰氯,Potassium Hydride,Sodium Hydride,二异丁基氢化铝,碳酸氢钠,Potassium Carbonate,戴斯-马丁氧化剂,N-甲基吗啉氧化物,三乙胺,N,N-二异丙基乙胺,三氟乙酸体系中,用 四氢呋喃,甲醇,乙醚,正己烷,二氯甲烷,环己烷,N,N-二甲基甲酰胺,丙酮,甲苯,乙腈 作为反应溶剂,化学反应 224.34H,反应生成 除莠霉素a
参考文献:Total Synthesis Of Herbimycin A
标题:Total Synthesis Of Herbimycin A
摘要:Hsp90 Has Recently Emerged As A Promising Biological Target For Treatment Of Cancer. Herbimycin A And Other Members Of The Benzoquinoid Ansamycin Class Of Natural Products Are Known To Inhibit Hsp90 Activity. The Total Synthesis Of Herbimycin A Was Achieved From The Commercially Available Roche Ester 1 By Using Allylmetals To Control The Stereogenic Centers At C6,C7,C10,C11,And C12 And A Ring-Closing Metathesis To Control The (Z)-Double Bond Of The (E,Z)-Dienic Moiety.
DOI:10.1021/ol062642I

专利信息

专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人：LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-9051302-B2
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
发明人：WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

专利号:US-5942494-A
优先权日:1995-10-06
标 题:Stimulation of gene expression and synthesis of heat shock protein 72/73 (HSP 70)
发明人：GINSBERG HENRY N; WU XUJUN; ZHOU MINGYUE
权利人:UNIV COLUMBIA
摘要:This invention provides a method for increasing the level of heat shock protein in a cell which comprises contacting the cell with an effective amount of N-acetyl-leucyl-leucyl-norleucinal, so as to thereby increase the level of heat shock protein in the cell. This invention further provides a protein characterized by increased levels of the protein in a cell in response to contacting the cell with an effective amount of N-acetyl-leucyl-leucyl-norleucinal. This invention also provides a method for increasing the binding of apoprotein B100 to a heat shock protein in a cell. This invention provides a method of preserving an organ ex vivo, which comprises contacting the organ with an effective amount of N-acetyl-leucyl-leucyl-norleucinal. This invention also provides a method of preserving an organ in vivo, which comprises contacting the organ with an effective amount of N-acetyl-leucyl-leucyl-norleucinal.

专利号:US-10443047-B2
优先权日:2014-05-01
标题 :Increasing cellular lipid production by increasing the activity of diacylglycerol acyltransferase and decreasing the activity of triacylglycerol lipase
发明人：TSAKRAKLIDES VASILIKI; BREVNOVA ELENA E
权利人:NOVOGY INC
摘要:Disclosed are methods and compositions for increasing the triacylglycerol content of a cell by up-regulating diacylglycerol acyltransferase and down-regulating triacylglycerol lipase. In some embodiments, a DGA1 protein is expressed and a native TGL3 gene is knocked out, thereby increasing the synthesis of triacylglycerol and decreasing its consumption, respectively.

专利号:US-2002111314-A1
优先权日:1995-10-06
标题 :Novel stimulation of gene expression and protein synthesis of heat shock protein 72/73 (Hsp 70)
发明人：GINSBERG HENRY N; WU XUJUN; ZHOU MINGYUE
权利人:UNIV COLUMBIA
摘要:This invention provides a method for increasing the level of heat shock protein in a cell which comprises contacting the cell with an effective amount of N-acetyl-leucyl-leucyl-norleucinal, so as to thereby increase the level of heat shock protein in the cell. This invention further provides a protein characterized by increased levels of the protein in a cell in response to contacting the cell with an effective amount of N-acetyl-leucyl-leucyl-norleucinal. This invention also provides a method for increasing the binding of apoprotein B100 to a heat shock protein in a cell. This invention provides a method of preserving an organ ex vivo, which comprises contacting the organ with an effective amount of N-acetyl-leucyl-leucyl-norleucinal. This invention also provides a method of preserving an organ in vivo, which comprises contacting the organ with an effective amount of N-acetyl-leucyl-leucyl-norleucinal.