CAS: 60956-26-5; 4-Bromo-2-Nitrotoluene

上下游产品

甲基硝基苯 1-Methyl-2-Nitrobenzene 88-72-2
4-甲基-3-硝基苯胺 4-Methyl-3-Nitroanilin 119-32-4
5-溴-2-甲基苯胺 5-Bromo-2-Methylaniline 39478-78-9
2-甲基-3-硝基-5-溴苯甲酸 5-Bromo-2-Methyl-3-Nitrobenzoic Acid 107650-20-4

在 Tetra-N-Butylammonium Tribromide体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 0.67H,以68%的收率获得产物4-溴-2-硝基甲苯
参考文献:使用三溴化四丁基铵或三碘化铯对有机三氟硼酸盐进行卤代硼烷化
标题:使用三溴化四丁基铵或三碘化铯对有机三氟硼酸盐进行卤代硼烷化
摘要:报道了在水介质中使用市售的三溴化四丁基铵(tbatb)或三碘化铯对有机三氟硼酸盐进行卤代硼烷化.事实证明,这种温和的不含过渡金属的方法可耐受多种官能团.观测到高的区域选择性和化学选择性.两个合成路线(ż)从炔-Dibromoalkenes,通过stereodefined(ż)-2-Bromoalkenyltrifluoroborates和(ž)-1,2-双(硼烷基)alkenyltrifluoroborates,已经使用tbatb介导bromodeboronation作为关键步骤开发的.
DOI:10.1016/j.Tet.2012.03.016

专利信息

专利号:US-8314090-B2
优先权日:2008-11-06
标 题:Methods of synthesis of benzazepine derivatives
发明人：HOWBERT J JEFFRY; KUSUKUNTLA VENKAT REDDY; TRETYAKOV ALEXANDER; NIELSEN NATHAN; KRASIK PAVEL; JIANG JI-LONG; YANG HONG WOON
权利人:HOWBERT J JEFFRY; KUSUKUNTLA VENKAT REDDY; TRETYAKOV ALEXANDER; NIELSEN NATHAN; KRASIK PAVEL; JIANG JI-LONG; YANG HONG WOON; VENTIRX PHARMACEUTICALS INC; ARRAY BIOPHARMA INC
摘要:The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry.

专利号:ES-2705101-T3
优先权日:2008-11-06
标 题:Methods of synthesis of benzazepine derivatives

专利号:CA-2742863-C
优先权日:2008-11-06
标题 :Methods of synthesis of benzazepine derivatives

专利号:AU-2009313392-B2
优先权日:2008-11-06
标题 :Methods of synthesis of benzazepine derivatives

专利号:EP-2358683-A1
优先权日:2008-11-06
标 题 :Methods of synthesis of benzazepine derivatives

专利号:AU-2009313392-A1
优先权日:2008-11-06
标题:Methods of synthesis of benzazepine derivatives