CAS: 56-17-7; 2,2'-Disulfanediyldiethanamine Dihydrochloride

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专利信息

专利号:US-9845501-B2
优先权日:1998-12-14
标题 :System and methods for nucleic acid sequencing of single molecules by polymerase synthesis
发明人：WILLIAMS JOHN G K
权利人:PACIFIC BIOSCIENCES CALIFORNIA INC; PACIFIC OF BIOSCIENCES OF CALIFORNIA INC
摘要:This invention relates to improved methods for sequencing and genotyping nucleic acid in a single molecule configuration. The method involves single molecule detection of fluorescent labeled PPi moieties released from NTPs as a polymerase extension product is created.

专利号:US-6987189-B2
优先权日:2001-05-31
标题:Short synthesis of pyridine-based pharmaceutical intermediates
发明人：COMINS DANIEL L; HUANG SHENLIN
权利人:UNIV NORTH CAROLINA STATE
摘要:A method of making a compound of Formula VI: n nwherein Tr is a triphenyl group; R 1 , R 2 and R 3 are each independently selected from the group consisting of H, C1–C4 alkyl, C1–C4 alkoxy, aryl, heteroaryl, and arylalkyl; R 4 is C2–C6 alkyl, and R 5 and R 6 are each independently H or C1–C4 alkyl, involves the step of reacting a compound of Formula V: n nwith Tr-OH to produce a compound of Formula VI. The compounds of Formula VI are useful as intermediates in the manufacture of antibiotic agents. Methods of making compounds of Formula V, and intermediates made or used in the foregoing methods, are also described.

专利号:US-5030738-A
优先权日:1986-03-28
标 题:Synthesis of antiulcer compounds
发明人：REINER ALBERTO
权利人:JANUS FARMA SRL
摘要:To synthesize molecules with antiulcer action, specifically ranitidine, niperotidine and cimetidine, having the formula: ##STR1## wherein R 1 is hydrogen or together with R 2 represents the rest of a cycloaliphatic or heterocyclic optionally substituted ring with 5 or 6 carbon atoms, R 2 represents H, alkyl, alkyl substituted with a simple or substituted aromatic ring or with a single or substituted heterocyclic ring, Ar represents a simple or substituted phenyl group, a simple or substituted heterocyclic aromatic group, N=1, 2, 3, 4, 5 or 6 and X represents CH--NO 2 , S, N--C.tbd.N, the compound (II) is prepared through the following process sequence: ##STR2## wherein Z=H, NO 2 , halogen and R 3 =--(CH 2 ) n Ar, --(CH 2 ) n --SH, --(CH 2 ) n --S--S--(CH 2 ) n , --(CH 2 ) n --S--CH 2 Ar Y being halogen. n The urea of formula ##STR3## is converted in a first stage into the corresponding carbodiimide ##STR4## by reaction with triphenylphosphine and bromine in the presence of a strong base and in a second stage is obtained the desired compound by reaction with nitromethane or with a saline derivative of cynamide.

专利号:WO-9511893-A1
优先权日:1993-10-27
标题 :Compounds and methods for synthesizing pantethine, pantetheine and derivatives thereof
发明人：PATIL GHANSHYAM
权利人:OCULON CORP
摘要:There is disclosed compounds and methods for the synthesis of pantethine, pantetheine, and derivatives thereof. The methods utilize crystalline derivatives of the above compounds as intermediates which readily permit purification by recrystallization, and thus allow the generation of highly pure products. The synthesis utilizes the 1,3-diol functional group present in pantothenic acid to produce the crystalline derivatives by formation of ketal intermediates. Subsequent hydrolisis of the ketal intermediates yields pantethine or pantetheine in highly pure form.

专利号:US-7205161-B2
优先权日:2001-01-10
标 题 :Polymer brushes for immobilizing molecules to a surface or substrate having improved stability
发明人：KLAERNER GERRIT; BENOIT DIDIER; CHARMOT DOMINIQUE; NOMULA SRINIVAS; PIOTTI MARCELO EDUARDO; MAZZOLA LAURA T
权利人:SYMYX TECHNOLOGIES INC
摘要:Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

专利号:US-6498150-B2
优先权日:1995-10-17
标 题 :Low molecular weight cell, bone marrow and immune stimulants
发明人：TAUB FLOYD; PERUN THOMAS J; MURRAY CHRISTOPHER K; DAUGHENBAUGH RANDALL J; LEDNICER DANIEL
权利人:DOVETAIL TECHNOLOGIES INC
摘要:The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.