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专利信息
专利号:WO-2011110511-A1
优先权日:2010-03-11
标题:Spect imaging agents of amyloid plaques
发明人:SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
权利人:Bayer Pharma AG; SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
摘要:The invention relates to novel iodine -radiolabeled compounds useful for diagnosing Alzheimer's desease, to respective novel precursors for the synthesis of such compounds, and to the process of manufacturing said imaging agent of the following Formula (I), wherein Q is a six membered aromatic ring, either carbocycle or heterocycle with one N- atom, wherein X 1 , X 2 , X 3 , X 4 and X 5 are independently selected from N or C, and wherein zero or one of X 1 ( X 2 , X 3 , X 4 or X 5 is N and the remaining ones are C; A is either Sn(alkyl)3, I, l-123, l-124, l-125, l-131, Br; wherein alkyl comprises methyl, ethyl, propyl, butyl, pentyl and hexyl, Y is C or N; with the proviso that if X 1 ( X 2 , X 3 , X 4 or X 5 has the meaning of N, substitution by A in that position is excluded; or a pharmaceutically acceptable salt thereof.
专利号:WO-2011095593-A1
优先权日:2010-02-08
标 题 :Iodo precursor for a pet imaging agent of amyloid plaques
发明人:SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
权利人:BAYER SCHERING PHARMA AG; SCHMITT-WILLICH HERIBERT; HEINRICH TOBIAS; BROCKSCHNIEDER DAMIAN
摘要:The invention relates to a precursor for a [ 18 F]-labeled PET tracer for imaging of Alzheimer's Disease, its synthesis and the process for preparing the respective [ 18 F]-labeled PET tracer.
专利号:US-9795613-B2
优先权日:2014-12-10
标题 :GLP-1 receptor modulators
发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL; GLYNN DANIEL; MILLS MARK
权利人:CELGENE INT II SÀRL
摘要:Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ †represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.
专利号:US-2011250135-A1
优先权日:2008-09-12
标 题 :Piperazine Derivatives for Binding and Imaging Amyloid Plaques and Their Use
发明人:SCHMITT-WILLICH HERIBERT; ROEHN ULRIKE; FRIEBE MATTHIAS; LEHMANN LUTZ; FITZNER ANSGAR; KRAUSE SABINE; BROCKSCHNIEDER DAMIAN; DYRKS THOMAS; THIELE ANDREA; BOEMER ULF; MOENNING URSULA; HEINRICH TOBIAS
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to compounds of formula I, their synthesis and their use, in particular for detecting amyloid deposits in a patient.
专利号:CN-111170991-B
优先权日:2014-07-11
标题 :Antiproliferative compounds and methods of synthesis thereof
专利号:CN-111170991-A
优先权日:2014-07-11
标 题:Antiproliferative compounds and methods of synthesis thereof