CAS: 52606-02-7; 2,4-Dimethoxypyrimidine-5-Carbaldehyde

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上下游产品

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2,4-二甲氧基-5-甲基嘧啶置于2,6-二甲基吡啶,Dipotassium Peroxodisulfate,硫酸,Copper(II) Sulfate体系中,用 水,乙腈 作为反应溶剂,化学反应 1.0H,以72%的收率获得产物2,4-二甲氧基5-嘧啶-甲醛
参考文献:Wittig烯化合成5-取代的尿嘧啶和2,4-二甲氧基嘧啶
标题:Wittig烯化合成5-取代的尿嘧啶和2,4-二甲氧基嘧啶
摘要:高纯度的各种新的5-烯基尿嘧啶是通过将稳定化的5-甲酰基-1-辛基-尿嘧啶,5-甲酰基-1,3-二辛基尿嘧啶和5-甲酰基-2,4-二甲氧基嘧啶进行wittig烯化反应而制得的.半稳定的磷化氢.基于1 H NMR光谱数据讨论产物的构象.
DOI:10.1002/jhet.5570420615

专利信息

专利号:US-6689806-B1
优先权日:1999-03-24
标 题 :Indolinone compounds as kinase inhibitors
发明人：TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS JR G DAVIS; LI XIAOYUAN; LIANG CONGXIN
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.