CAS: 496-14-0; Phthalan

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CAS号612-14-6 邻苯二甲醇 | CAS号91-13-4 α,α'-二溴邻二甲苯 | CAS号612-12-4 邻二氯苄 | CAS号62172-88-7 2-(甲氧基甲基)苯甲醇 | CAS号106020-70-6 2-(甲氧基甲基)苯甲醛 | CAS号95-47-6 邻二甲苯 | CAS号583-57-3 1,2-二甲基环己烷 | CAS号2105-40-0 2-甲基环己烷甲醇 | CAS号4385-35-7 3-异色酮 | CAS号180068-03-5 1-butyl-1,3-dih... | CAS号89-95-2 邻甲基苄醇 | CAS号87-41-2 苯酞 | CAS号85-44-9 苯酐

苯酞置于aluminium(Iii) Triflate,三(乙酰丙酮酸)钌(Iii),氢气,1,1,1-三(二苯基膦甲基)乙烷体系中,用 四氢呋喃 作为反应溶剂,130.0 °C,4.05 Mpa 条件下,反应 10.0H,以90%的收率获得产物1,3-二氢异苯并呋喃
参考文献:路易斯酸通过羧酸/酯的选择性加氢促进钌(II)催化的醚化
标题:路易斯酸通过羧酸/酯的选择性加氢促进钌(II)催化的醚化
摘要:醚在有机化学中至关重要,是有价值的香精,香料和多种生物活性化合物的组成部分.通常,酯的还原构成醚的最直接的制备.不幸的是,这种转变需要大量的金属氢化物.本文提出了一种双功能催化剂体系,其由ru /膦配合物和三氟甲磺酸铝组成,其允许通过酯或羧酸的氢化选择性地合成醚.不同的内酯以非常好的产率降低为所需产物.甚至具有挑战性的芳族和脂族酯也被还原为所需的产物.值得注意的是,原位形成的催化剂可以重复使用几次,而不会显着降低活性.
DOI:10.1002/anie.201500062

专利信息

专利号:US-6639059-B1
优先权日:1999-03-24
标 题 :Synthesis of [2.2.1]bicyclo nucleosides
发明人：KOCHKINE ALEXEI; FENSHOLDT JEF; PFUNDHELLER HENRIK M
权利人:EXIQON AS
摘要:A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such as 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose, intermediates of the general formula III are suitable for coupling with silylated nucleobases. Upon one-pot base-induced ring-closure and desulfonation of the formed [2.2.1]bicyclo nucleoside, a short route to each the LNA (Locked Nucleic Acid) derivatives of adenosine, cytosine, uridine, thymidine and guanidine is demonstrated. The use of the 5'-sulfonated ring-closed intermediate also allows for synthesis of 5'-amino- and thio-LNAs.

专利号:US-6734291-B2
优先权日:1999-03-24
标题:Synthesis of [2.2.1]bicyclo nucleosides
发明人：KOCHKINE ALEXEI; FENSHOLDT JEF; PFUNDHELLER HENRIK M
权利人:EXIQON AS
摘要:A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such as 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose, intermediates of the general formula III are suitable for coupling with silylated nucleobases. Upon one-pot base-induced ring-closure and desulfonation of the formed [2.2.1]bicyclo nucleoside, a short route to each the LNA (Locked Nucleic Acid) derivatives of adenosine, cytosine, uridine, thymidine and guanidine is demonstrated. The use of the 5'-sulfonated ring-closed intermediate also allows for synthesis of 5'-amino- and thio-LNAs

专利号:US-6998484-B2
优先权日:2000-10-04
标 题:Synthesis of purine locked nucleic acid analogues
发明人：KOCH TROELS; JENSEN FLEMMING REISSIG
权利人:SANTARIS PHARMA AS
摘要:The present invention relates to a new method for the synthesis of purine LNA (Locked Nucleic Acid) analogues which provides a higher overall yield. The method comprising a regioselective 9-N purine glycosylation reaction followed by a one-pot nucleophilic aromatic substitution reaction of the 6-substituent in the purine ring and simultaneous nucleophile-induced intramolecular ring closure of the C-branched carbohydrate to form novel purine LNA analogues. The novel strategy is illustrated by the synthesis of the novel compound (1S,3R,4R,7S)-7-benzyloxy-1-methanesulfonylmethyl-3-(guanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane which is easily converted into (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-((2-N-isobutyrylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane after isobutyryl protection of the 2-amino purine group and subsequent substitution of 1-methanesulfonyl with benzoate, debenzoylation and debenzylation.

专利号:US-7842834-B2
优先权日:2005-07-21
标 题:Process for the synthesis of sulfonyl halides and sulfonamides from sulfonic acid salts
发明人：MICHALAK RONALD S; HELOM JEAN L; ZELDIS JOSEPH
权利人:WYETH LLC
摘要:The present invention provides synthetic processes for the preparation of sulfonyl halides of Formula Ar—(R) z —SO 2 —X and sulfonamides of Formula Ar—(R) z —SO 2 —NR 4 R 5 , where the constituent variables are as defined herein, that are useful as intermediates in the preparation of pharmaceuticals.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-9185909-B2
优先权日:2007-09-17
标 题:Synthesis of resveratrol-based natural products
发明人：SNYDER SCOTT ALAN; BREAZZANO STEVEN P; ROSS AUDREY G; LIN YUNQING; ZOGRAFOS ALEXANDROS L
权利人:SNYDER SCOTT ALAN; BREAZZANO STEVEN P; ROSS AUDREY G; LIN YUNQING; ZOGRAFOS ALEXANDROS L; UNIV COLUMBIA
摘要:Processes for synthesizing resveratrol-based oligomers are provided. In addition, resveratrol-based oligomer compounds free of plant extract are provided.