CAS: 350-50-5; (Fluoromethyl)Benzene

上下游产品

CAS号100-51-6 苯甲醇 | CAS号100-39-0 溴化苄 | CAS号100-44-7 氯化苄 | CAS号103-82-2 苯乙酸 | CAS号373-53-5 氟碘甲烷 | CAS号24388-23-6 苯硼酸频呐醇酯 | CAS号1024-41-5 benzyl 4-methyl... | CAS号55791-06-5 甲磺酸苄酯 | CAS号28925-45-3 O-phenylmethyl-... | CAS号882-33-7 二苯二硫醚 | CAS号6852-58-0 N-二甲氨基苄叔丁胺 | CAS号3378-72-1 N-叔丁基苄胺 | CAS号1944-01-0 1-苯甲基环己醇 | CAS号620-47-3 3-benyl toluol | CAS号620-83-7 4-甲基二苯甲烷 | CAS号713-36-0 2-甲基二苯甲烷 | CAS号100-39-0 溴化苄 | CAS号772-54-3 N-苄基二乙胺 | CAS号770-09-2 苄基三甲基硅烷 | CAS号539-30-0 苄基乙基醚

📜苄基甲基硫醚置于cesium Fluoride体系中,用 二氯甲烷 用作溶剂,化学反应 40.0H,反应生成氟甲苯
参考文献:A Facile Method For The Fluorine Substitution Of Phenylthio Groupviasulfonium Salts Using Cesium Fluoride
标题:A Facile Method For The Fluorine Substitution Of Phenylthio Groupviasulfonium Salts Using Cesium Fluoride
摘要:单氟化合物通过将苯基硫化物与氟磺酸甲酯和氟化铯在回流的二氯甲烷中顺序处理,能够以非常好的收率轻易制备.该反应在温和条件下进行,不会影响共存的溴取代基.
Doi:10.1246/cl.1987.1985

专利信息

专利号:US-2010016607-A1
优先权日:2006-12-11
标题:Process for the Synthesis of Highly Active Binary Metal Fluoride as a Fluorinating Agent for Aromatics
发明人：DOLBIER JR WILLIAM R; JANMANCHI KRISHNA MURTHY
权利人:UNIV FLORIDA
摘要:The subject invention relates to a process for the synthesis of highly active binary metal fluoride system for the fluorination of aromatic compounds. Fluorinated aromatic compounds are valuable synthons for the chemical synthesis of pharmaceutical drugs and novel polymers. Fluorobenzene is used to control carbon content in steel manufacturing, is an intermediate for pharmaceuticals, pesticides and other organic compounds. Fluorobenzene is typically produced by the reaction of aniline and sodium nitrite in the presence of hydrogen fluoride. The present invention relates to a process for the synthesis of highly active binary metal fluoride system consists of copper (II) fluoride and aluminum (III) fluoride for the fluorination of aromatic compounds in gas phase and recycling of the reagent, in situ, using O 2 and HF.

专利号:US-3852307-A
优先权日:1972-04-25
标 题 :Synthesis of zearalanone and related compounds
发明人：URRY W; MULLENBACH G
权利人:COMMERCIAL SOLVENTS CORP
摘要:WHEREIN X is an integer having a value from 0 to 6 inclusive and Y is an integer having a value from 3 to 8 inclusive. It also provides for new methods of making compounds useful in the synthesis of zearalanone and related compounds. The compounds 6-acetoxyhexanoic acid; 2-(5-hexenoyl)cyclohexanone; 7-keto-11-dodecenoic acid; 2-hydroxyethyl 7-keto11-dodecenoate ethylene ketal; N,N-dimethyl 7-keto-11dodecenamide ethylene ketal; 7-keto-11-dodecenal ethylene ketal; 9-keto-2,13-tetradecadienic acid ethylene ketal; 2-hydroxyethyl 9-keto-2,13-tetradecadienoate ethylene ketal; the sodium salt of ethyl 6-(6-keto-10-undecenyl)- Beta -dihydroresorcylate ethylene ketal; ethyl 3-bromo-6-(6-keto-10-undecenyl)- Beta dihydroresorcylate ethylene ketal; ethyl 6-(6-keto-10-undecenyl)Beta -resorcylate ehtylene ketal; ethyl 6-(6-keto-10-undecenyl)Beta -resorcylate ethylene ketal dibenzyl ether; ethyl 6-(6keto-10-hydroxyundecyl)- Beta -resorcylate ethylene ketal dibenzyl ether; and 6-(10-hydroxy-6-keto-undecyl)- Beta resorcylic acid dibenzyl ether are disclosed. Methods for preparing these compounds are also disclosed. This invention provides a new synthesis for zearalanone and for related compounds having more or fewer carbon atoms in the nonaromatic ring than does zearalanone, which related compounds and zearalanone are represented by the formula

专利号:US-6800785-B1
优先权日:2002-10-15
标题:Process for the synthesis of estrogen receptor modulators
发明人：MENG DONGFANG
权利人:MERCK & CO INC
摘要:The present invention relates to processes for the synthesis of intermediates useful for the synthesis of estrogen receptor modulators. The process includes new methods for annelating 5-, 6- and 7-membered cycloalkenones onto an indanone.

专利号:US-6187925-B1
优先权日:1997-12-23
标 题 :Intermediates and process for the synthesis of azasteroids
发明人：HUMPHREY GUY R; MILLER ROSS A; LI WENJIE
权利人:MERCK & CO INC
摘要:The novel process of this invention involves the stereoselective synthesis of certain 16-substituted 4-aza-5alpha-androst-1-en-3-ones, and the useful intermediates obtained therein.

专利号:US-5880295-A
优先权日:1994-02-16
标 题 :Process for the preparation of diamine intermediates useful in the synthesis of HIV protease inhibitors
发明人：KALTENBACH III ROBERT FRANK
权利人:DU PONT PHARM CO
摘要:The present invention provides a process for the preparation of compounds of formula (V) below, and analogs thereof, which are useful as intermediates for the synthesis of HIV protease inhibitors, including cyclic ureas. ##STR1##

专利号:US-2010150835-A1
优先权日:2007-02-27
标题:Synthesis of [18F] Fluoromethyl Benzene Using Benzyl Pentafluorobenzenesulfonate
发明人：LANGSTROM BENGT; KARIMI FARHAD; BLOM ELISABETH
权利人:LANGSTROM BENGT; KARIMI FARHAD; BLOM ELISABETH
摘要:The present invention discloses the reactivity of ponytail (“PTâ€?) sulfonates as leaving groups in nucleophilic fluorination reactions. The results showed that using a pentafluorobenzenesulfonate precursor is a suitable leaving group for n. c. a. nucleophilic 18 F-fluorination in synthesis of [ 18 F]fluoromethyl benzene, wherein this is a suitable leaving group for 18F-labeling with moderate reactivity. The PT-precursor seems to be quite stable. In an attempt to purify the crude 18F-labeled product using fluorous solid phase extraction (F-SPE), the radio labeled impurities decreased significantly. This provides an opportunity for utilizing PT methodology in both simple and fast purification methods.