CAS: 3260-85-3; 4-Chloro-1-Methoxy-2-Methylbenzene

上下游产品

CAS号578-58-5 邻甲基苯甲醚 | CAS号7035-09-8 5-氯-2-甲氧基苯甲醛 | CAS号1570-64-5 4-氯-2-甲基苯酚 | CAS号77-78-1 硫酸二甲酯 | CAS号95-48-7 邻甲酚 | CAS号74-88-4 碘甲烷 | CAS号104-93-8 4-甲基苯甲醚(MSO) | CAS号7782-50-5 氯气 | CAS号321-14-2 5-氯代水杨酸 | CAS号3438-16-2 5-氯-2-甲氧基苯甲酸

2-甲基苯甲醚置于iron(Iii) Chloride,N-氯代丁二酰亚胺,1-丁基-3-甲基咪唑二(三氟甲基磺酰)酰亚胺体系中,用 四氢呋喃 作为反应溶剂,化学反应 24.0H,以85%的收率获得产物4-氯-2-甲基苯甲醚
参考文献:铁(iii)催化的芳烃氯化反应
标题:铁(iii)催化的芳烃氯化反应
摘要:已经开发了用于活化的芳烃氯化的通用的和区域选择性的方法.该转化过程使用三氟甲磺酸铁(iii)作为强力的路易斯酸来活化n-氯代琥珀酰亚胺和随后的氯化过程,将各种苯甲醚,苯胺,对乙酰苯胺和苯酚衍生物进行氯化.该反应用于一系列目标化合物的后期单氯化和二氯化反应,这些目标化合物例如是天然产物硝苯芬净,抗菌剂氯氧lenol和除草剂氯己腈.一锅,串联,铁催化的二卤化过程的发展证明了这种转变的简便性,可以高度区域选择性地形成不同的碳-卤键.通过合成天然产物和药物相关靶标,建立了所得二卤代芳基化合物作为结构单元的合成效用.
DOI:10.1021/acs.Joc.7B01225

专利信息

专利号:US-9018371-B2
优先权日:2007-03-07
标 题 :Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient
发明人：JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH
权利人:JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH; FM THERAPEUTICS CO LTD; US OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES THE OFFICE OF TECHNO
摘要:Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A 3 adenosine receptors and act as A 3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-9676721-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.

专利号:US-9555039-B2
优先权日:2011-05-09
标题:Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT)
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)

专利号:US-9169209-B2
优先权日:2011-05-04
标题:Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BAUMEISTER TIMM; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and composition for inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.

专利号:WO-2008108508-A1
优先权日:2007-03-07
标题 :Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient