CAS: 2361-27-5; 2-Thiophenecarboxylic Acid Hydrazide

上下游产品

CAS号5380-42-7 2-噻吩甲酸甲酯 | CAS号2810-04-0 噻吩-2-羧酸乙酯 | CAS号527-72-0 2-噻吩甲酸 | CAS号1204708-00-8 1,3-dicyclohexy... | CAS号527-72-0 2-噻吩甲酸 | CAS号5380-42-7 2-噻吩甲酸甲酯 | CAS号2810-04-0 噻吩-2-羧酸乙酯 | CAS号65183-21-3 2-(thiophen-2-y... | CAS号187795-50-2 4-烯丙基-5-噻吩-2-基-... | CAS号27049-71-4 5-噻吩-2-基-1,3,4-... | CAS号68744-66-1 4-甲基-5-(2-噻吩)-4... | CAS号61019-27-0 4-氨基-5-(2-噻吩)-2... | CAS号128772-83-8 5-噻吩-2-基-1,3,4-... | CAS号10551-15-2 5-(2-噻吩)-1,3,4-...

📜2-噻吩甲酸置于硫酸,一水合肼体系中,用 乙醇 用作溶剂,化学反应 32.0H,反应生成2-噻吩甲酰肼
参考文献:新型1,3,4-恶二唑类似物作为有效的抗微生物剂和抗结核剂的分子性质预测和合成
标题:新型1,3,4-恶二唑类似物作为有效的抗微生物剂和抗结核剂的分子性质预测和合成
摘要:在本研究中,一系列1,5-二甲基-2-苯基-4-{[((5-芳基-1,3,4-恶二唑-2-基)甲基]氨基]氨基}-1,2-二氢-使用alogps 2.1程序,通过molinspiration(molinspiration,2008)和molsoft(molsoft,2007)软件对3 H-吡唑-3-酮进行分子性质预测,药物相似性,亲脂性和溶解度参数.合成了遵循lipinski" 5条规则"的化合物,作为口服生物可利用的药物/导线用于抗菌和抗结核病筛查.发现化合物4A的最大药物相似模型得分(0.95).所有合成的化合物通过ir,NMR和质谱分析进行表征,然后进行抗菌和抗分枝杆菌筛选.在标题化合物中,化合物4D分别显示出对结核分枝杆菌h 37 Rv和耐异烟肼结核分枝杆菌(inhr-Tb)的显着活性,最低抑菌浓度(mic)分别为0.78μm和1.52μm.与标准药物环丙沙星相比,化合物4A对mic
Doi:10.1016/j.Bmcl.2011.10.057

专利信息

专利号:US-2021323987-A1
优先权日:2018-08-20
标题:Methods for the Synthesis of Heteroatom Containing Polycyclic Aromatic Hydrocarbons
发明人：GARG NEIL K; DARZI EVAN R; BARBER JOYANN S; SUSICK ROBERT; CHARI JASON; SPENCE KATIE
权利人:UNIV CALIFORNIA
摘要:Methods for the synthesis of polycyclic aromatic hydrocarbons and synthesis platforms for performing such syntheses are provided. Methods and platforms are provided that allow for the synthesis of aza-polycyclic aromatic hydrocarbons by an expedient ring assembly. Methods and platforms allow for a modular approach to synthesis that provide multiple new C—C bonds in sequential pericyclic reactions, thus giving access to compounds with multiple axes of substitution.

专利号:US-6291504-B1
优先权日:1999-10-20
标题:Acylsemicarbazides and their uses
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP P; YUE EDDY W
权利人:DU PONT PHARM CO
摘要:The present invention relates to the synthesis of a new lass of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-2002142011-A1
优先权日:2000-06-16
标题 :Vaccine
发明人：PARISH TANYA; SMITH DEBBIE
摘要:A mycobacterium attenuated by a mutation in a gene such as the proC or trpD that expresses a product which promotes synthesis of proline or tryptophan is used in a method of vaccinating a host. The mycobacterium may be Mycobacterium tuberculosis or Mycobacterium bovis.

专利号:RU-2189985-C2
优先权日:1999-04-30
标 题 :Method of synthesis of derivative of 8-cyclo-pentyl-6-ethyl-3- (substituted)-5,8-dihydro-4h-1,2,3a,7,8-pentaaza-ac-indacene (variants) and intermediate compounds

专利号:WO-0234721-A1
优先权日:2000-10-20
标 题:Acylsemicarbazides and their use as cyclin dependent kinase (cdk) inhibitors
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP; YUE EDDY W
权利人:DU PONT PHARM CO
摘要:The present invention realtes to the synthesis fo a new class of indeno [1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. The invention also provides a novel method of treating cancer or otehr profiferative disease by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative disease by administering a therapeutically effective combination of one of the compounds of teh present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-2006211603-A1
优先权日:2004-08-18
标 题:Ramoplanin derivatives possessing antibacterial activity
发明人：RAJU BORE G; CIABATTI ROMEO; MAFFIOLI SONIA I; SINGH UPINDER; ROMANO GABRIELLA; MICHELUCCI ELENA; TISENI PAOLO S; CANDIANI GIANPAOLO; KIM BUM; O'DOWD HARDWIN
权利人:VICURON PHARM INC
摘要:Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.