CAS: 21427-62-3; 2,5-Dichloro-3-Nitropyridine

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CAS号5409-39-2 2-氨基-5-氯-3-硝基吡啶 | CAS号21427-61-2 5-氯-2-羟基-3-硝基吡啶 | CAS号75-44-5 光气 | CAS号4214-79-3 5-氯-2-吡啶醇 | CAS号105544-27-2 ethyl 2-(5-chlo... | CAS号181123-11-5 5-氯-2-氰基-3-硝基吡啶 | CAS号22353-52-2 5-氯-2-甲氧基-3-硝基吡啶 | CAS号78607-32-6 2,5-二氯-3-氨基吡啶 | CAS号1211533-93-5 5-氯-2-甲基-3-硝基吡啶 | CAS号136888-12-5 6-氯4-氮杂-吲哚-2-酮 | CAS号886373-70-2 5-氯-2-甲氧基吡啶-3-胺 | CAS号89639-36-1 5-氯-2-甲基吡啶-3-胺 | CAS号923033-74-3 5-chloro-2-[(2-... | CAS号923033-77-6 5-chloro-2-[(1-...

5-氯-2-羟基吡啶置于氯化亚砜,硫酸,硝酸体系中,用 水,N,N-二甲基甲酰胺 用作溶剂,化学反应 21.0H,反应生成2,5-二氯-3-硝基吡啶
参考文献:作为氨基糖原合酶激酶3(gsk-3)抑制剂的8-氨基-[1,2,4]三唑并[4,3-A ]吡啶-3(2 H)-One衍生物的合成与评价
标题:作为氨基糖原合酶激酶3(gsk-3)抑制剂的8-氨基-[1,2,4]三唑并[4,3-A ]吡啶-3(2 H)-One衍生物的合成与评价
摘要:通过建模,合成设计了新的强力糖原合酶激酶3(gsk-3)抑制剂8-氨基-[1,2,4]三唑并[4,3-A ]吡啶-3(2 H)-One衍生物.并进行了体外评价.化合物17C在基于酶和细胞的测定中显示出非常好的效价(ic 50 = 111 Nm,Ec 50 = 1.78μm).此外,已证明其具有理想的水溶性,Pk曲线和适度的大脑渗透能力.
Doi:10.1016/j.Bmcl.2013.03.119

专利信息

专利号:US-6001329-A
优先权日:1996-05-06
标 题 :Radiolabeled fusion toxins for cancer therapy
发明人：BUCHSBAUM DONALD J; BLAZAR BRUCE R; VALLERA DANIEL A
权利人:UAB RESEARCH FOUNDATION
摘要:The present invention provides the synthesis and purification of a new class of compounds known as radiolabeled fusion toxins (RFT), in which both toxin and radionuclide tags are contained on the same growth factor, for example, murine granulocyte macrophage colony stimulating factor, mGM-CSF, epidermal growth factor, or murine interleukin-4, mIL-4.

专利号:CA-2035710-A1
优先权日:1990-02-16
标题:Benzimidazole aqnd azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparatin, synthesis interm ediates and pharmaceutical compositions in which they are prsent

专利号:IE-910339-A1
优先权日:1990-02-16
标 题 :Novel benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation, synthesis intermediates and pharmaceutical compositions in which they are present