CAS: 20845-34-5; 1-Methyl-2-Piperidinemethanol

相似化合物

136030-04-1 68474-13-5 157634-00-9

上下游产品

2-哌啶甲醇 2-Piperidinemethanol 3433-37-2
1-甲基哌啶-2-羧酸 1-Methylpiperidine-2-Carboxylic Acid 7730-87-2
1-甲基-2-哌啶甲酸甲酯 Methyl 1-Methyl-2-Piperidinecarboxylate 1690-74-0

N-Boc-2-哌啶甲酸置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 用作溶剂,化学反应 4.0H,以100%的收率获得1-甲基-2-哌啶甲醇
参考文献:构象受限的2-(1-吡咯烷基)-N-[2-(3,4-二氯苯基)乙基]-N-甲基亚乙基二烯的合成和生物学评估.1.吡咯烷,哌啶,高哌啶和四氢异喹啉类.
标题:构象受限的2-(1-吡咯烷基)-N-[2-(3,4-二氯苯基)乙基]-N-甲基亚乙基二烯的合成和生物学评估.1.吡咯烷,哌啶,高哌啶和四氢异喹啉类.
摘要:描述了一系列2-(1-吡咯烷基)-N-[2-(3,4-二氯苯基)乙基]-N-甲基乙二胺(1)的构象受限衍生物的合成和sigma受体亲和力.该sigma受体药效基团的吡咯烷基(或n,N-二烷基),乙二胺,N-烷基和苯乙基部分受其并入1,2-环己烷二胺-,吡咯烷-,哌啶-,高哌啶-和四氢异喹啉-的限制.含有配体.使用[3H](+)-喷他佐辛在豚鼠脑匀浆中测定这些化合物的sigma受体结合亲和力.除一类外,所有的合成都通过适当的二胺前体的酰化和烷烃还原来实现,该二胺前体的合成也已有报道.Sigma受体亲和力范围为1.34 Nm(对于6)(1R,2R)-反-N-[2-(3,4-二氯苯基)乙基]-N-甲基的7-二氯-2-[2-(1-(吡咯烷基)乙基]四氢异喹啉(12)至455 Nm-2-(1-吡咯烷基)环己胺[(-)-4].在该置换试验中,(+)-戊唑嗪的ki值为3.1 Nm,而dtg和氟哌啶醇的ki值分别为27
Doi:10.1021/jm00101A011

专利信息

专利号:US-5637757-A
优先权日:1995-04-11
标 题 :One-pot synthesis of ring-brominated benzoate compounds
发明人：HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH
权利人:GREAT LAKES CHEMICAL CORP
摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.

专利号:US-6566525-B1
优先权日:1998-09-17
标 题:Preparation of N-substituted-hydroxycycloalkylamine derivatives
发明人：KIM SEONG JIN; KIM KEON IL; YANG KYOUNG YOUL
权利人:SAMSUNG FINE CHEMICALS CO LTD
摘要:A process for the preparation of N-substituted-hydroxycycloalkylamine derivatives, that are useful intermediates for the synthesis of various organic chemicals including pharmaceutical and agrochemical compounds, represented by formula (1), by reacting a 1,2-dihydroxalkyl alcohol, represented by the following formula (2), with a thionyl halide to produce an intermediate 1,2-cyclosulfinylalkyl halide represented by the following formula (3); and then cyclizing that intermediate with an amine compounds represented by the following formula (4).In the above structural formuli, * represents an asymmetric carbon atom; R1 is hydrogen or an amino-protecting group; m is an integer of 1-3; and X is halogen. The reactant compounds as well as the compounds made according to this invention have the following substitution pattern:n=1, R2=OH, R3=H and m=1; n=1, R2=H, R3=CH2OH and m=2;n=2, R2=OH, R3=H; and m=2; and n=2, R2=H, R3=CH2OH and m=3.

专利号:US-10118824-B2
优先权日:2013-12-17
标题:Process for purifying synthesis gas by washing with aqueous solutions of amines
发明人：CHICHE DAVID; PIERRON ANNE CLAIRE; ULLRICH NORBERT
权利人:SOFIPROTEOL; AXENS; IFP ENERGIES NOW; BIONEXT; THYSSENKRUPP IND SOLUTIONS AG; TOTAL RAFFINAGE CHIMIE; COMMISSARIAT ENERGIE ATOMIQUE; AVRIL
摘要:The invention relates to a process for purifying synthesis gas, comprising at least one stage for separating the crude synthesis gas to be treated into at least two effluents, namely a first part and a complementary part, in which the said first part is subjected to a carbon monoxide conversion stage with steam and the said complementary part is subjected to a COS and HCN catalytic hydrolysis stage, the two gas flows, namely the first part and complementary part, are then each treated separately in two stages intended to remove acid gases such as CO 2 and H 2 S, by washing with aqueous solutions of specific amines, before a recombination stage of the two treated effluents.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-6225341-B1
优先权日:1995-02-27
标 题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:WO-9632368-A1
优先权日:1995-04-11
标题:One-pot synthesis of ring-brominated benzoate compounds