Tert-Butyl 4-[(2,2-Dimethyl-4,6-Dioxo-1,3-Dioxan-5-Ylidene)(Hydroxy)Methyl]Piperidine-1-Carboxylate置于sodium Hydroxide体系中,用 水 用作溶剂,化学反应 28.0H,反应生成4-乙酰基哌啶-1-甲酸叔丁酯 参考文献:Meso-Piperidine Calix[4]Pyrrole: Synthesis,Structure And Ion Binding Studies 标题:Meso-Piperidine Calix[4]Pyrrole: Synthesis,Structure And Ion Binding Studies 摘要:We Report The Synthesis,Structure And Preliminary Solution Phase Ion Binding Properties Of The Calix[4] Pyrrole 3A-C. Calix[4]Pyrrole 3A And 3B,The First To Be Prepared Via One-Pot Reaction,Were Obtained By Reacting The Ketone 7 With Pyrrole In The Presence Of An Acid Catalyst. On The Basis Of H-1 NMR Spectroscopic Analyses And The Titrations Of Uv Spectrophotometry,It Was Concluded That Compound 3A Possesses Significantly Enhanced Selectivity For Fluoride Anion In Chloroform,And Formes 1:1 (Ligand: Anion) Complexes With Fluoride And Chloride Anions. (C) 2015 Elsevier Ltd. All Rights Reserved. Doi:10.1016/j.Tet.2015.08.032
专利号:US-6407103-B2 优先权日:1998-04-21 标 题:Indeno [1,2-c] pyrazol-4-ones and their uses 发明人:NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W 权利人:BRISTOL MYERS SQUIBB PHARMA CO 摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
专利号:WO-2015088565-A1 优先权日:2013-12-13 标题:P2x4 receptor modulating compounds and methods of use thereof 发明人:NEWCOM JASON S; SPEAR KERRY L 权利人:SUNOVION PHARMACEUTICALS INC 摘要:Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.
专利号:CN-118147098-B 优先权日:2024-04-22 标题 :Leucine dehydrogenase mutants and their applications in the synthesis of chiral nitrogen heterocyclic amines
专利号:US-5919792-A 优先权日:1996-10-30 标题 :Integrin antagonists 发明人:DUGGAN MARK E; HARTMAN GEORGE D; HOFFMAN WILLIAM F; IHLE NATHAN C 权利人:MERCK & CO INC 摘要:This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are αvβ3 antagonists, αvβ5 antagonists or dual αvβ3/αvβ5 antagonists useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation and tumor growth.
专利号:US-8178531-B2 优先权日:2010-02-23 标 题:Antiviral agents 发明人:OR YAT SUN; WANG GUOQIANG; GAO XURI 权利人:OR YAT SUN; WANG GUOQIANG; GAO XURI; ENANTA PHARM INC 摘要:The present invention relates to antiviral compounds of formula (I), n ncompositions containing these compounds, processes for their preparation, intermediates in their synthesis, and their use as therapeutics for prevention of organ transplantation rejection, the treatment of immune disorders and inflammation, and treatment of viral (particularly hepatitis C viral) infection.
专利号:US-6358970-B1 优先权日:1999-06-23 标题:Integrin receptor antagonists 发明人:DUGGAN MARK E; HARTMAN GEORGE D; PERKINS JAMES J; IHLE NATHAN 权利人:MERCK & CO INC 摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphavbeta3 and/or alphavbeta5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.