CAS: 17585-59-0; (S)-2-Aminosuccinic Acid Hydrochloride

相似化合物

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CAS号70-47-3 L-天冬酰胺 | CAS号97-67-6 L-苹果酸

📜L-天冬酰胺置于盐酸体系中,化学反应 16.0H,反应生成L-天门冬氨酸盐酸盐
参考文献:Neopetrosiamides,来自海洋海绵neopetrosia Sp.的肽.抑制了人类肿瘤细胞对类阿米巴的入侵.
标题:Neopetrosiamides,来自海洋海绵neopetrosia Sp.的肽.抑制了人类肿瘤细胞对类阿米巴的入侵.
摘要:[结构:参见正文]从海洋海绵neopetrosia Sp.中分离出了两种新的非对映异构的三环肽,它们能抑制变形虫入侵人类肿瘤细胞,它们分别是neopetrosiamdes A(1)和b(2).收集在巴布亚新几内亚.通过分析ms和NMR数据阐明新石油硅酰胺的结构,并通过化学降解证实.
Doi:10.1021/ol051524C

专利信息

专利号:WO-9221675-A1
优先权日:1991-06-03
标题:Synthesis of optically active lactones from l-aspartic acid and intermediates thereof

专利号:EP-0643710-A1
优先权日:1991-06-03
标 题 :Synthesis of optically active lactones from l-aspartic acid and intermediates thereof

专利号:US-5322942-A
优先权日:1991-06-03
标题 :Synthesis of optically active lactones from L-aspartic acid and intermediates thereof
发明人：RAPOPORT HENRY; DENER JEFFREY M; ZHANG LIN-HAU
权利人:UNIV CALIFORNIA
摘要:Optically active lactones are described, such as an intermediate lactone having the formula ##STR1## where R and R 2 are each independently alkyl with 1 to 6 carbon atoms, cycloalkyl with 6 to 10 carbon atoms, aryl with 6 to 10 carbon atoms, or arylalkyl with 7 to 19 carbon atoms, R 4 is H or C 1-6 alkyl, and Ar is a homo- or heteroaromatic ring with 5 or 6 ring atoms being optionally substituted by C 1-6 alkyl or alkoxy groups, halogen atoms, cyano or nitro groups. Such optically active, intermediate lactones are prepared from L-aspartic acid, and can be readily converted to (+)-pilocarpine and its analogues by hydrolysis, reduction, and hydrogenation, such as to an optically active lactone having the formula ##STR2## which is (+)-pilocarpine when R is ethyl, R 4 is H, and Ar is 1-methylimidazol-5-yl.