CAS: 173932-75-7; (Z)-4-((1R,3As,5S,12As)-9-((E)-3,7-Dimethylocta-2,6-Dien-1-yl)-8,10-Dihydroxy-2,2-Dimethyl-11-(3-Methylbut-2-En-1-yl)-4,7-Dioxo-1,2,5,7-Tetrahydro-1,5-Methanofuro[2,3-D]Xanthen-3A(4H)-yl)-2-Methylbut-2-Enoic Acid
- 英文名称(Z)-4-((1R,3As,5S,12As)-9-((E)-3,7-Dimethylocta-2,6-Dien-1-yl)-8,10-Dihydroxy-2,2-Dimethyl-11-(3-Methylbut-2-En-1-yl)-4,7-Dioxo-1,2,5,7-Tetrahydro-1,5-Methanofuro[2,3-D]Xanthen-3A(4H)-yl)-2-Methylbut-2-Enoic Acid
- 中文名称新藤黄酸
- IUPAC名称(Z)-4-((1R,3aS,5S,12aS)-9-((E)-3,7-dimethylocta-2,6-dien-1-yl)-8,10-dihydroxy-2,2-dimethyl-11-(3-methylbut-2-en-1-yl)-4,7-dioxo-1,2,5,7-tetrahydro-1,5-methanofuro[2,3-d]xanthen-3a(4H)-yl)-2-methylbut-2-enoic acid
- 其它别名2-butenoic Acid,4-[(1R,3As,5S,12As)-9-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3A,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl
- CAS编号173932-75-7
- MFCD编号:MFCD32173486
- 分子式:C38H46O8分子量:630.78
- 产品CID: 888608
- 产品分类Protein Tyrosine Kinase/RTK → FGFR | Inhibitors/Agonists → Epigenetics → Histone Methyltransferase
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
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主要参考文献
1: Xu L, Meng X, Xu N, Fu W, Tan H, Zhang L, Zhou Q, Qian J, Tu S, Li X, Lao Y, Xu H. Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth. Cell Death Dis. 2018 Feb 15;9(3):262. doi: 10.1038/s41419-018-0314-6.
2: Liu P, Wu X, Dai L, Ge Z, Gao C, Zhang H, Wang F, Zhang X, Chen B. Gambogenic Acid Exerts Antitumor Activity in Hypoxic Multiple Myeloma Cells by Regulation of miR-21. J Cancer. 2017 Sep 16;8(16):3278-3286. doi: 10.7150/jca.19290. eCollection 2017.
3: Li F, Wang Y, Yan Y. Gambogenic acid induces cell growth inhibition, cell cycle arrest and metastasis inhibition in choroidal melanoma in a dose-dependent manner. Exp Ther Med. 2017 May;13(5):2456-2462. doi: 10.3892/etm.2017.4252. Epub 2017 Mar 22.
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