CAS: 134179-38-7; Amino-Peg3-C2-Azido

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642091-68-7 951671-92-4 1207714-69-9

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CAS号101187-39-7 1,11-二叠氮基-3,6,9... | CAS号112-60-7 三缩四乙二醇 | CAS号55400-73-2 Ms-PEG4-Ms | CAS号86770-67-4 11-叠氮基-3,6,9-三氧杂十一醇 | CAS号134179-43-4 methanesulfonic... | CAS号134179-42-3 1-azido-11-[(te... | CAS号65883-12-7 PEG4-Ms | CAS号239081-53-9 2-[2-[2-[2-[2-(... | CAS号875770-34-6 N-[2-[2-[2-(2-叠... | CAS号65883-12-7 PEG4-Ms

📜13,13,14,14-四甲基-3,6,9,12-四氧杂-13-硅-1-十五醇置于盐酸,Sodium Azide,四丁基氟化铵,一水合肼,三乙胺体系中,用 四氢呋喃,乙二醇二甲醚,乙醇,二氯甲烷 用作溶剂,化学反应 18.0H,反应生成1-氨基-11-叠氮-3,6,9-三氧杂十一烷
参考文献:The Synthesis Of Heterobifunctional Linkers For The Conjugation Of Ligands To Molecular Probes
标题:The Synthesis Of Heterobifunctional Linkers For The Conjugation Of Ligands To Molecular Probes
摘要:
Doi:10.1021/jo00013A053

专利信息

专利号:US-9623125-B2
优先权日:2011-10-24
标 题:Controlled synthesis of polyglutamates with low polydispersity and versatile architectures
发明人：VICENT DOCON MARIA JESUS; BARZ MATTHIAS; CANAL FABIANA; CONEJOS SANCHEZ INMACULADA; DURO CASTANO AROA; ENGLAND RICHARD MARK
权利人:FUND DE LA COMUNIDAD VALENCIANA “CENTRO DE INVESTIG PRINCIPE FELIPEâ€?
摘要:Polyglutamates are well known to be highly biocompatible, biodegradable and multifunctional polymers, which have been already used as building blocks in polymer drug conjugates and polymeric micelles. Those systems have been applied to various medical applications ranging from therapy to molecular imaging. Furthermore a polyglutamic acid (PGA) paclitaxel conjugate has already entered clinical studies (Opaxioâ„¢ PGA-PTX conjugate currently in phase III of Clinical trials). n In this context, a synthetic pathway to a plethora functional polyglutamates (homopolymers, block-co-polymers, tribocks) with well-defined structure, adjustable molecular weight (Mw) and low dispersity (D=Mw/Mn<1.2) applying the ring opening polymerization (ROP) of N-carboxyanhydrides (NCA) has been developed. Additionally, the acid moieties of the polyglutamates can be activated with 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium (DMTMM) and various functionalities can be easily introduced by “post-polymerization modificationâ€? yielding a set orthogonal reactive attachment sides. The reactive moieties, such as azides, maleimides, thiols, akynes (linear or cyclic) offer the opportunity of specific conjugation of the drugs, targeting moieties or markers. Besides introducing reactive groups the functionalization strategy was also used for PEGylation of PGA reducing charge induced interactions and therefore pharmacological properties, such as blood circulation time may be adjusted. n In summary, a tool kit of various polyglutamates has been developed enabling the synthesis of a variety of polymer drug conjugates or polymer based imaging agents. The functional polymeric precursors developed will allow us to functionalize and therefore adjust the polymer properties to a desired aplication.

专利号:US-8877171-B2
优先权日:2010-02-03
标 题 :Polyanionic multivalent macromolecules for intracellular targeting of proliferation and protein synthesis
发明人：LICHA KAI; SCHIRNER MICHAEL; WELKER PIA; HAAG RAINER; WEINHART MARIE; PAULUS FLORIAN
权利人:LICHA KAI; SCHIRNER MICHAEL; WELKER PIA; HAAG RAINER; WEINHART MARIE; PAULUS FLORIAN; MIVENION GMBH
摘要:The present invention relates generally to methods and compositions for targeting of intracellular molecules involved in proliferation and protein synthesis of activated cells using polyanionic multivalent macromolecules. In particular aspect, multiple sulfate groups linked to polyol are specifically targeted to the cytoplasm and nucleus of proliferating and activated cells. The invention further comprises novel polyanionic macromolecular compounds and formulations.

专利号:US-7038037-B2
优先权日:2002-06-20
标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds
发明人：MAIER MARTIN A; GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging molecule having at least two N-protecting amino groups. A conjugated oligomeric compound for therapeutic or prophylactic delivery is also disclosed.

专利号:US-8071718-B2
优先权日:2004-12-22
标题:Selective radiolabeling of biomolecules
发明人：PADILLA DE JESUS OMAYRA LIZ; KOVACS ERNEST WILLIAM; GLASER MATTHIAS EBERHARD; ARSTAD ERIK; SYUD FAISAL AHMED
权利人:PADILLA DE JESUS OMAYRA LIZ; KOVACS ERNEST WILLIAM; GLASER MATTHIAS EBERHARD; ARSTAD ERIK; SYUD FAISAL AHMED; GEN ELECTRIC
摘要:Provided herein are methods for introducing fluorine atom onto a biomolecule comprising: (i) providing a linker comprising a thiol-reactive terminus and an azido/alkyne-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a biomolecule comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the azido/alkyne-reactive terminus of the linker with a fluorine-substituted azide or alkyne respectively. Also provided are compositions and method of synthesis of bifunctional linkers and bioconjugates as well as radio-diagnostic agents comprising fluorine-labeled biomolecules.

专利号:US-9926595-B2
优先权日:2008-03-19
标 题:Methods and solutions for inhibiting undesired cleaving of labels
发明人：OLEJNIK JERZY; GUGGENHEIM EVAN; MEYYAPPAN VISALAKSHI
权利人:INTELLIGENT BIOSYSTEMS INC; INTELLIGENT BIO SYSTEMS INC
摘要:The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.

专利号:US-8231858-B2
优先权日:2003-02-10
标 题 :Diagnostic imaging agents with MMP inhibitory activity
发明人：STOREY ANTHONY; DAVIS JULIE; RICKETTS SALLY-ANN; MENDIZABAL MARIVI; CUTHBERTSON ALAN; ARUKWE JOSEPH; HEYWOOD KIRSTY; WILSON IAN; WYNN DUNCAN; SCHAFERS MICHAEL; LEVKAU BODO; WAGNER STEFAN; BREYHOLZ HANS-JOERG; KOPKA KLAUS
权利人:STOREY ANTHONY; DAVIS JULIE; RICKETTS SALLY-ANN; MENDIZABAL MARIVI; CUTHBERTSON ALAN; ARUKWE JOSEPH; HEYWOOD KIRSTY; WILSON IAN; WYNN DUNCAN; SCHAFERS MICHAEL; LEVKAU BODO; WAGNER STEFAN; BREYHOLZ HANS-JOERG; KOPKA KLAUS; GE HEALTHCARE LTD
摘要:The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.