CAS: 133-17-5; Sodiumo-Iodohippurate

专利信息

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-2008207523-A1
优先权日:2006-09-08
标题 :Compounds as aptamer-dimers and their uses in diagnosis and therapy
发明人：FRIEBE MATTHIAS; STEPHENS ANDREW; SRINIVASAN ANANTH; HECHT MAREN
权利人:FRIEBE MATTHIAS; STEPHENS ANDREW; SRINIVASAN ANANTH; HECHT MAREN
摘要:The object of the present invention is solved by compositions of peptide linkers and their use for synthesis and annealing of aptamer oligonucleotides in form of dimers. The present invention in particularly provides said compositions for the use as a diagnostic and/or therapeutic agent. n In another preferred embodiment the present invention relates to a kit for preparing a radiopharmaceutical preparation, said kit comprising a vial comprising a quantity of the compound according to the invention. n A further preferred embodiment of the present invention relates to methods of producing said compounds, comprising synthesis of said compound in an automated peptide synthesizer. n In another preferred embodiment the present invention concerns the use of said compounds according to the present invention for the manufacture of a medicament, preferably for diagnosis or therapy of proliferative diseases. n In a further preferred embodiment the present invention concerns methods for treating or diagnosing patients administering or utilizing the compounds according to the present invention.

专利号:US-5980861-A
优先权日:1996-03-12
标题 :Chelator compositions and methods of synthesis thereof
发明人：HNATOWICH DONALD J; RUSCKOWSKI MARY; MARDIROSSIAN GEORGE; WINNARD JR PAUL; CHANG FENGCHUN
权利人:UNIV MASSACHUSETTS
摘要:Compositions of radiolabeled nucleic acids and methods for synthesis and use thereof are disclosed.

专利号:WO-03086476-A1
优先权日:2002-04-08
标 题 :Technetium-labeled rotenone derivatives, and methods of use thereof
发明人：BABICH JOHN W; MARESCA KEVIN P
权利人:BIOSTREAM INC; BABICH JOHN W; MARESCA KEVIN P
摘要:One aspect of the present invention relates to Tc-99m-labeled rotenone derivatives. These derivatives are useful, for example, as myocardial blood flow imaging agents. Reported herein are the synthesis, radiolabeling, and testing of Tc-99m-labeled rotenone complexes as single photon emitting probes for improved delineation of myocardial perfusion. The Tc-99m-rotenone derivatives have unique properties. The instant invention also relates to technetium-99m-labeled rotenone derivatives which exhibit high uptake and retention in the myocardium in proportion to flow. Another aspect of the present invention relates to kits compring a Tc-99m-labeled rotenone derivative.

专利号:WO-9733626-A1
优先权日:1996-03-12
标 题:Novel chelators and compositions prepared therewith
发明人：HNATOWICH DONALD J; RUSCKOWSKI MARY; MARDIROSSIAN GEORGE; WINNARD PAUL JR; CHANG FENGCHUN; QU TONG
权利人:UNIV MASSACHUSETTS; HNATOWICH DONALD J; RUSCKOWSKI MARY; MARDIROSSIAN GEORGE; WINNARD PAUL JR; CHANG FENGCHUN; QU TONG
摘要:Novel chelators and methods of synthesis and use thereof are disclosed. The compositions, methods and kits provided enable radionuclides for medical applications to be complexed to chelator-conjugates under mild conditions.