CAS: 98349-24-7; Ethyl 2,4,5-Trifluorobenzoylacetate

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CAS号1071-46-1 丙二酸单乙酯 | CAS号88419-56-1 2,4,5-三氟苯甲酰氯 | CAS号6148-64-7 丙二酸单乙酯钾盐 | CAS号98349-22-5 2,4,5-三氟苯甲腈 | CAS号446-17-3 2,4,5-三氟苯甲酸 | CAS号123-91-1 1,4-二氧六环 | CAS号104600-15-9 (2,4,5-trifluor... | CAS号129322-83-4 2',4',5'-三氟苯乙酮 | CAS号105-58-8 碳酸二乙酯 | CAS号327-52-6 2,4,5-三氟溴苯 | CAS号108138-27-8 1-(2,4-difluoro... | CAS号93106-60-6 恩诺沙星 | CAS号98106-17-3 双氟沙星 | CAS号98105-99-8 沙拉沙星 | CAS号93107-30-3 1-环丙基-6,7-二氟-1,... | CAS号85721-33-1 环丙沙星 | CAS号103994-99-6 6,7-二氟-1-(4-氟苯基... | CAS号113046-72-3 6,7-二氟-1-甲基-4-氧... | CAS号189279-58-1 德拉沙星 | CAS号154330-68-4 4-乙酰氧基-6,7-二氟-2...

2,2-Dichlorovinyl 2,4,5-Trifluorophenyl Ketone置于硫酸,Sodium体系中,用 乙醇,二氯甲烷 作为反应溶剂,化学反应生成 2,4,5-三氟苯甲酰乙酸乙酯
参考文献:Preparation Of Halogenated Aroylacetic Acid Esters
标题:Preparation Of Halogenated Aroylacetic Acid Esters
摘要:一种制备卤代芳香乙酸酯的方法,其化学式为##str1##其中r为含有1-6个碳原子的烷基,X和x.Sup.2各自独立为卤素,X.Sup.1和x.Sup.3各自独立为氢或卤素,包括在无水氯化铝存在下,将化学式为##str2##的苯甲酰氯与二氯乙烯反应,形成相应的苯三氯乙基酮,脱氯化三氯乙基酮形成相应的苯二氯乙烯基酮,并将二氯乙烯基酮与醇酸盐和水酸反应.这些产物是已知抗菌药物的已知中间体.

专利信息

专利号:US-7642356-B2
优先权日:2005-09-16
标 题 :Process for preparing beta-ketoester compounds
发明人：SHIN HYUN IK; CHOI BO SEUNG; LEE JAE HOON
权利人:LG LIFE SCIENCES LTD
摘要:The present invention relates to a process for preparing a beta-keto ester compound of formula (1), which is an intermediate for the synthesis of quinolone antibiotics. Particularly, the present invention is characterized by the reaction of an organo nitrile compound with a salt of mono-alkyl malonate in the presence of metal salt, and so the reaction is easy to control due to its endothermic nature, and is devoid of lachrymatory reagents with excellent reproducibility. Subsequent in situ hydrolysis in the presence of aqueous acid solution provided the compound of formula (1).

专利号:US-6566520-B2
优先权日:1997-03-27
标题 :Support for synthesis and purification of compounds
发明人：DEWITT SHEILA HELEN; RAMAGE ROBERT; MACDONALD ALASDAIR ARTHUR
权利人:WARNER LAMBERT CO
摘要:A method for the preparation and purification of compounds using a novel support, a tetrabenzo [a, c, g, i]-fluorene group (Tbf) comprising reacting a building block (A) containing a Tbf group (Tbf-A), with a second building block (B), to afford an intermediate compound (Tbg-A-B) followed by purifying the intermediate compound by adsorption on a carbon support, removing the intermediate compound from the support with a solvent and repeating the previous reactions using the required number of building blocks to synthesize the compounds followed by removal of the Tbf group to afford the desired compounds.

专利号:US-6987199-B2
优先权日:2001-10-15
标题 :Process for preparing beta-ketoester compound
发明人：SHIN HYUN-LK; CHOI BO-SEUNG; CHOI SANG-CHUL
权利人:LG LIFE SCIENCES LTD
摘要:The present invention relates to a new process for preparing beta-ketoester compound of the following formula (1), which is a useful intermediate for the synthesis of such quinoline antibiotics as Ciprofloxacin, Levofloxacin, Gemifloxacin, Trovafloxacin, etc. The quinoline antibiotics obtained from the above compound of formula (1) show potent antibacterial activity, and so are advantageously used as a therapeutic agent for bacterial infections of humans or animals.

专利号:CN-104803934-B
优先权日:2015-05-04
标 题:A kind of phenylisoxazole carboxylic acid compound with antitumor activity and its synthesis method and application

专利号:US-5977400-A
优先权日:1997-03-27
标题:Support for synthesis and purification of compounds

专利号:US-2003077651-A1
优先权日:1997-03-27
标题 :Novel support for synthesis and purification of compounds