CAS: 95095-84-4; 3-Amino-6-Chloropyridine-2-Carbonitrile

该化合物是环环环的杂环化合物,含有氨基氨基化合物和环环基氨酸化合物;六点方位氯原子和三点方座氨基氮化合物的存在有助于其反应性及药用化学和农用化学的潜在应用;该化合物一般在室温和极地有机溶剂中是固体的,可溶解于极地的有机溶液;其结构允许进行各种化学修改,使其在合成更复杂的分子时成为多功能的中间体;该环基化学品组增强了其参与核感激反应的能力,而氨基生物组可参与氢结合,影响其物理特性和相互作用;作为具有特定化学文摘社编号的复合体,该化合物在化学数据库中可以识别,促进各个领域的研究和开发,包括制药和材料科学;应当参考安全数据,以便处理和储存,如同任何化学物质一样,处理和存储.

英文名称3-Amino-6-Chloropyridine-2-Carbonitrile
中文名称3-氨基-6-氯-2-吡啶甲腈
IUPAC名称3-amino-6-chloropicolinonitrile
其它别名3-氨基-6-氯吡啶-2-甲腈; 3-Amino-6-Chloropicolinonitrile
CAS编号95095-84-4
MFCD编号:MFCD07780767
EINECS号:964-644-2
分子式:C6H4ClN3分子量:153.57
产品CID: 2003240
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: GGQNLFCQZACXET-UHFFFAOYSA-N
InChI=1S/C6H4ClN3/c7-6-2-1-4(9)5(3-8)10-6/h1-2H,9H2
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数*

相似化合物

866807-27-4 93683-65-9 175358-01-7

MSDS等安全信息

GHS符号GHS07
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

欧盟法规

C&L通报

上下游产品

6-chloro-3-nitropicolinonitrile 2,6-dicholoro-3-nitropyridine iron 2,6-dichloropyridine 6-chloropyrido[3,2-d]pyrimidine-2,4-diamine 6-(4-Methoxy-phenylsulfanyl)-pyrido[3,2-d]pyrimidine-2,4-diamine 6-(2-Methoxy-phenylsulfanyl)-pyrido[3,2-d]pyrimidine-2,4-diamine 6-(3,4-Dimethoxy-phenylsulfanyl)-pyrido[3,2-d]pyrimidine-2,4-diamine

合成工艺路线路线简述

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Tetrabutylammonium Bromide Solvents: Dichloromethane,Water; Overnight,Rt
标题:4,6-Disubstituted Pyrido[3,2-D]Pyrimidine Compound,Its Preparation And Application In Preparation Of Mnk Inhibitor And Drug For Treating And/or Preventing Various Cancers And/or Metabolic Diseases
参考文献:China]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Acetic Acid Solvents: Water; 20 Min,Rt1.2 Reagents: Sodium Dithionite; Rt; 2 H,Rt
标题:Pyrido[3,2-D]Pyrimidines As Immunosuppressive Agents,And Their Preparation,Pharmaceutical Compositions And Use In Medical Treatment
参考文献:United States]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Acetic Acid Solvents: Water; 20 Min,Rt1.2 Reagents: Sodium Dithionite; Rt; 2 H,Rt
标题:Preparation Of Pyrido(3,2-D)Pyrimidines And Use As Immunosuppressive Prodrugs
参考文献:World Intellectual Property Organization]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Iron,Hydrochloric Acid Solvents: Methanol,Water; 45 Min,Reflux1.2 Reagents: Ammonium Hydroxide Solvents: Water; Basified
标题:Cyclic Regimens Using Cyclic Urea And Cyclic Amide Derivatives
参考文献:World Intellectual Property Organization]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Sodium Dithionite Catalysts: Tetrabutylammonium Bromide Solvents: Dichloromethane,Water; 3 H,30 °C
标题:Synthesis And Biological Evaluation Of Substituted 1,2,3-Benzotriazines And Pyrido[3,2-D]-1,2,3-Triazines As Inhibitors Of Vascular Endothelial Growth Factor Receptor-2
作者:Zhao,Xing-Wang; Liu,Dan; Luan,Sheng-Lin; Hu,Guo-Dong; Lv,Jin-Ling; Et Al
参考文献:Bioorganic & Medicinal Chemistry 日期:2013 卷标:21(24) 页码:7807-7815]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Iron,Hydrochloric Acid Solvents: Methanol; Reflux
标题:Pyrimidine Derivatives,Preparation,And Therapeutic Use
参考文献:United States]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Iron,Hydrochloric Acid Solvents: Ethanol,Water; Reflux; 30 Min,Reflux1.2 Reagents: Water; Cooled1.3 Reagents: Ammonium Hydroxide Solvents: Water; Basified
标题:Preparation Of Arenotriazine Derivatives As Tyrosine Kinase Inhibitors For Treatment Of Cancer
参考文献:China]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Tetrabutylammonium Bromide,Sodium Dithionite Solvents: Dichloromethane,Water; Overnight,Rt
标题:Optimization Of 4,6-Disubstituted Pyrido[3,2-D]Pyrimidines As Dual Mnk/pim Inhibitors To Inhibit Leukemia Cell Growth
作者:Han,Yu; Zhang,Huimin; Wang,Shuxiang; Li,Bo; Xing,Kun; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2021 卷标:64(18) 页码:13719-13735]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Acetic Acid Solvents: Water; 20 Min,Rt1.2 Reagents: Sodium Dithionite; Rt; 2 H,Rt
标题:Preparation Of Pyrido[3,2-D]Pyrimidines For Treating Hepatitis C Infection
参考文献:World Intellectual Property Organization]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Stannous Chloride Solvents: Ethanol; 2 H,Reflux
标题:Substituted Azaquinazolinones As Modulators Of Ghsr-1A For The Treatment Of Type Ii Diabetes And Obesity
作者:Hanrahan,Patrick; Bell,James; Bottomley,Gillian; Bradley,Stuart; Clarke,Phillip; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2012 卷标:22(6) 页码:2271-2278]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Iron,Hydrochloric Acid Solvents: Methanol; 45 Min,Reflux1.2 Reagents: Ammonium Hydroxide Solvents: Water; Basified
标题:Preparation Of Cyclic Urea And Cyclic Amide Derivatives As Agonists And Antagonists Of The Progesterone Receptor
参考文献:World Intellectual Property Organization]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Acetic Acid,Sodium Dithionite Solvents: Water; 20 °C; 12 H,60 °C
标题:6-Heterocycloalkylquinazoline Derivatives As Anticancer Agents And Their Preparation
参考文献:World Intellectual Property Organization]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Sodium Thiosulfate Solvents: Dichloromethane,Water; 3.5 H,Rt1.2 Reagents: Potassium Carbonate Solvents: Water; 30 Min,Neutralized,Rt
标题:Design And Synthesis Of Substituted Pyrido[3,2-D]-1,2,3-Triazines As Potential Pim-1 Inhibitors
作者:Fan,Yin-Bo; Li,Kun; Huang,Min; Cao,Yu; Li,Ying; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2016 卷标:26(4) 页码:1224-1228]

93683-65-9 = 95095-84-4 [标题:Reaction Conditions
标题:Synthesis And Antimalarial Properties Of 2,4-Diamino-6-[(Aryl)Thio,Sulfinyl,And Sulfonyl]Pyrido[3,2-D]Pyrimidines
作者:Colbry,Norman L.; Elslager,Edward F.; Werbel,Leslie M.
参考文献:Journal Of Heterocyclic Chemistry 日期:1984 卷标:21(5) 页码:1521-5]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Iron,Hydrochloric Acid Solvents: Ethanol,Water; Rt; 30 Min,Reflux1.2 Reagents: Sodium Bicarbonate Solvents: Water; Basified
标题:Preparation Of Cyclohexylpyridine Derivatives With Nk1 Receptor Antagonistic Action And Suppressed Cyp3A4 Inhibitory Action,And Pharmaceutical Compositions Containing Them
参考文献:World Intellectual Property Organization]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Iron,Hydrochloric Acid Solvents: Ethanol,Water; Rt; 10 Min,Rt -> Reflux
标题:Preparation Of (Carboxymethyl)Piperidine Derivatives As Nk1 Receptor Antagonists For Treatment And Prevention Of Antitumor Agent-Induced Nausea And Vomiting
参考文献:World Intellectual Property Organization]

93683-65-9 = 95095-84-4
反应条件:1.1 Reagents: Iron,Hydrochloric Acid Solvents: Methanol; Reflux
标题:Preparation Of Pyrrolopyrimidines,Furopyrimidines,Pyridopyrimidines,And Related Compounds As Inhibitors Of Dihydrofolate Reductase And Thymidylate Synthase.
参考文献:United States]

= 95095-84-4 [标题:Reaction Conditions
标题:Pyrazole-Containing Derivative,Pharmaceutically Acceptable Salt Thereof,Preparation Method Therefor And Application Thereof
参考文献:World Intellectual Property Organization]

= 95095-84-4 [标题:Reaction Conditions
标题:Preparation Of Pyrido[3,2-D]Pyrimidines As Immunosuppressive Agents
参考文献:World Intellectual Property Organization

📜6-氯-2-氰基-3-硝基吡啶置于盐酸,铁粉体系中,用甲醇作为反应溶剂,化学反应 0.5H,以34%的收率获得产物3-氨基-6-氯嘧啶-2-腈基
参考文献:2,4-二氨基-6-[(芳基)硫代,亚磺酰基和磺酰基]吡啶并[3,2-D]嘧啶的合成及抗疟药性能†
标题:2,4-二氨基-6-[(芳基)硫代,亚磺酰基和磺酰基]吡啶并[3,2-D]嘧啶的合成及抗疟药性能†
摘要:描述了一系列2,4-二氨基-6-[(芳基)硫代,亚磺酰基和磺酰基]吡啶基-[3,2-D]嘧啶的合成和抗疟活性.2,6-二氯吡啶的硝化提供了3-硝基衍生物,其被氰化亚铜转化为6-氯-3-硝基-2-吡啶腈(v).芳基硫醇与v的缩合得到6-芳基硫代吡啶vi,将其在盐酸中用铁还原,再与氯甲am缩合,得到6-芳基硫代吡啶并[3,2-D]嘧啶-2,4-二胺x.还原成与氯甲am缩合的胺the,然后用芳硫醇处理所得的6-氯吡啶并[3,2-D]嘧啶(ix).x的氧化提供了亚磺酰基和磺酰基类似物.
DOI:10.1002/jhet.5570210556