CAS: 877-95-2; N-Phenethylacetamide

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CAS号64-04-0 β-苯乙胺 | CAS号75-36-5 乙酰氯 | CAS号108-24-7 乙酸酐 | CAS号66417-92-3 N-(4-phenylbuta... | CAS号84304-09-6 Acetic acid,1-(... | CAS号60-35-5 乙酰胺 | CAS号64-19-7 冰醋酸 | CAS号75-07-0 乙醛 | CAS号140-29-4 苯乙腈 | CAS号101137-71-7 tert-butyl N-ac... | CAS号88422-94-0 1-(N-乙酰基氨基)-2-(... | CAS号105871-20-3 N-[2-(2-chlorop... | CAS号41472-49-5 N-[2-[4-(氨基磺酰基)... | CAS号14300-08-4 Acetamide,N-nit... | CAS号1721-93-3 1-甲基异喹啉 | CAS号20335-59-5 1-methyl-5-nitr... | CAS号79-20-9 乙酸甲酯 | CAS号64-04-0 β-苯乙胺 | CAS号23279-64-3 4-(2-(N-乙酰氨基)乙基)苯乙酮 | CAS号69447-84-3 4-硝基苯乙胺氢溴酸盐

📜2-苯乙胺盐酸盐置于三乙胺,乙酰氯体系中,用 二氯甲烷 作为反应溶剂,化学反应 5.0H,以13.9 G的收率获得产物n-(2-苯乙基)乙酰胺
参考文献:双胍类探针及其制备方法
标题:双胍类探针及其制备方法
摘要:本发明提出了化合物,其制备方法及在制备试剂盒中的用途,筛选药物靶标的方法以及确定样本中是否存在药物靶标的方法.所述化合物具有:活性基团;以及潜在报告基团,其中,所述活性基团具有下式所示的结构,所述潜在报告基团为炔基.本发明的化合物能够特异性识别并结合双胍类药物的体内作用靶标,不影响细胞的通透性,且易于观察,分离,纯化靶蛋白.化合物同时兼具双胍类药物活性,对于双胍类药物的体内作用靶标以及药物与靶标的作用模式,活性位点等结构信息的研究具有重要意义.

专利信息

专利号:US-11414375-B2
优先权日:2016-07-29
标题:Mild and efficient preparation method for α-acyloxyenamide compounds and use thereof in synthesis of amide and polypeptide
发明人：ZHAO JUNFENG; HU LONG; XU SILIN; ZHAO ZHENGUANG
权利人:UNIV JIANGXI NORMAL
摘要:Disclosed are a mild and efficient preparation method for an α-acyloxyenamide compound and a use thereof in the synthesis of an amide and a polypeptide. The α-acyloxyenamide compound is obtained by an addition reaction of a ynamide and a carboxylic acid in dichloromethane under conditions where the temperature is 0° C. to 50° C.; the produced α-acyloxyenamide compound can react with an amine compound to produce an amide or a polypeptide; the two reactions can be carried out step by step, and can also be carried out in one pot. According to the invention, the reaction conditions are mild and no metal catalyst is required; when the carboxylic acid, which has chirality on an alpha site of carboxyl, forms an amide bond or a peptide bond, no racemization occurs; and the operation is simple and the application range is wide.

专利号:US-8188282-B2
优先权日:2006-07-15
标 题:Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS; SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

专利号:US-2020299226-A1
优先权日:2016-07-29
标题:Mild and efficient preparation method for a-acyloxyenamide compounds and use thereof in synthesis of amide and polypeptide

专利号:US-10836707-B2
优先权日:2016-07-29
标 题:Mild and efficient preparation method for α-acyloxyenamide compounds and use thereof in synthesis of amide and polypeptide

专利号:AU-2007276514-A1
优先权日:2006-07-15
标题:A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CA-2657717-A1
优先权日:2006-07-15
标 题 :A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles