合成目标产物 Phthalylsulfathiazole 主要起始原料 Phthalic Anhydride And Sulfathiazole
72-14-0 = 85-73-4 反应条件:1.1 Catalysts: Benzoic Acid 标题:Solid-Phase Interaction Of Phthalic Anhydride With Norsulfazol During Their Simultaneous Dispersion 作者:Chuev,V. P.; Et Al 参考文献:Sibirskii Khimicheskii Zhurnal 日期:1991 卷标:(1) 页码:133-9]
72-14-0 = 85-73-4 反应条件:1.1 Reagents: Benzoic Acid1.2 Reagents: Water; 75 - 80 °C 标题:On The Mechanism Of Mechanochemical Synthesis Of Phthalylsulphathiazole 作者:Mikhailenko,M. A.; Et Al 参考文献:Journal Of Materials Science 日期:2004 卷标:39(16-17) 页码:5435-5439]
72-14-0 = 85-73-4 [标题:Reaction Conditions 标题:Solid-Phase Mechanochemical Acylation. Application In Pharmaceutical Synthesis 作者:Chuev,V. P.; Et Al 参考文献:Sibirskii Khimicheskii Zhurnal 日期:1991 卷标:(5) 页码:158-9
4-(1,3-Dioxoisoindolin-2-yl)-N-(2-Thiazolyl)Benzenesulfonamide置于氢氧化钾体系中,化学反应生成 酞磺胺噻唑 参考文献:Picard Et Al.,Journal Of The Chemical Society,1948,P. 821 标题:Picard Et Al.,Journal Of The Chemical Society,1948,P. 821
专利号:US-7109377-B2 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products 发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R 权利人:HARVARD COLLEGE 摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:US-8399502-B2 优先权日:2008-09-17 标 题 :Analogs of indole-3-carbinol and their use as agents against infection 发明人:JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN 权利人:JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN; STANFORD RES INST INT 摘要:Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.
专利号:US-2003082830-A1 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:US-2007021349-A1 优先权日:2005-04-28 标题:Orthogonally protected bifunctional amino acid 发明人:SRINIVASAN ANANTH; LUYT LEONARD G 权利人:SRINIVASAN ANANTH; LUYT LEONARD G 摘要:The present invention concerns novel orthogonally protected amino acids, there production and use for the synthesis of binding compounds usable in the diagnosis and treatment of proliferative diseases, in particular tumor diseases.
专利号:WO-0006525-A9 优先权日:1998-07-25 标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:WO-0006525-A2 优先权日:1998-07-25 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
1: FLORESTANO HJ, KENNEDY JF. Observations on the activity in vitro of succinylsulfathiazole and phthalylsulfathiazole. J Lab Clin Med. 1946 Jul;31(7):757-62. J Am Med Assoc. 1945 Dec 15;129:1080-3. Gastroenterology. 1950 Dec;16(4):782-4. Undetermined Language. Undetermined Language. Spanish. Arch Surg. 1946 Aug;53:182-9. J Biol Chem. 1946 Oct;165(2):431-5. Czech. Chinese. Portuguese. French.
合成参考文献
摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664 参考文献:10.1007/bf02231364|10.1007/bf02231377|10.1007/bf02231381 摘要:HIGHTOWER NC, BRODERS AC, HAINES RD, McKENNEY JF, SOMMER AW. Chronic ulcerative colitis. I. Diagnostic considerations. Am J Dig Dis. 1958 Oct;3(10):722–33. doi: 10.1007/bf02231364. 参考文献:10.1080/00034983.1996.11813090 摘要:Woods KM, Nesterenko MV, Upton SJ. Efficacy of 101 antimicrobials and other agents on the development ofCryptosporidium parvum in vitro. Annals of Tropical Medicine & Parasitology. 1996 Jan;90(6):603–15. doi: 10.1080/00034983.1996.11813090. 参考文献:10.1007/bf02231458 摘要:Levitan R, Kramer P. Reactivation of ulcerative colitis following closure of an ileostomy of 27 years' duration. Digestive Diseases and Sciences. 1960 Sep;5(9):815–23. doi: 10.1007/bf02231458.