CAS: 81732-48-1; 5-Acetyl-1,3-Phenylene Bis(Dimethylcarbamate)

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3,5-dihydroxyacetophenone N,N-Dimethylcarbamoyl chloride 1-(3',5'-diacetoxyphenyl)ethanone

📜3,5-二乙酰氧基苯乙酮置于potassium Carbonate体系中,用 四氢呋喃,N,N-二甲基甲酰胺,异丙醇 作为反应溶剂,化学反应 66.5H,反应生成 5-乙酰基-1,3-亚苯基二(二甲基氨基甲酸酯)
参考文献:Synthesis Of (R)-Bambuterol Based On Asymmetric Reduction Of 1-[3,5-Bis(Dimethylcarbamoyloxy)Phenyl]-2-Chloroethanone With Incubated Whole Cells Of Williopsis Californica Jcm 3600
标题:Synthesis Of (R)-Bambuterol Based On Asymmetric Reduction Of 1-[3,5-Bis(Dimethylcarbamoyloxy)Phenyl]-2-Chloroethanone With Incubated Whole Cells Of Williopsis Californica Jcm 3600
摘要:To Achieve The Synthesis Of (R)-Bambuterol,A Prodrug Of (R)-Terbutaline,Asymmetric Reduction Of 1-[3,5-Bis(Dimethylcarbamoyloxy)Phenyl]-2-Chloroethanone With Whole Cells Of Williopsis Californica Jcm 3600 Pre-Incubated On Glycerol As A Carbon Source Was Examined. Initially,The Insolubility Of This Crystalline Substrate (Mp 126-127 Degrees C) In The Incubation Broth Was An Obstacle That Needed To Be Overcome. To Solve The Problem,The Concentration Of Glycerol Was Increased To 10% During Reduction. Glycerol Worked Well For Recycling Oxido-Reduction Cofactors And For Enhancing The Water Solubility Of The Substrate. The Reduction Proceeded Smoothly To Give Enantiomerically Pure (R)-Alcohol In 81% Isolated Yield. (C) 2013 Elsevier B.V. All Rights Reserved.
DOI:10.1016/j.Molcatb.2013.08.003