CAS: 72784-43-1; Methyl 1-Aminocyclopropanecarboxylate

该化合物是一种环丙烷衍生物,具有氨基氨基和酯功能组,使其成为有机合成的多用途中间体,其累累累环丙烷环能增强反应性,有利于在生物活性化合物(包括药品和农用化学品)的制作过程中应用,该酯组的存在允许进一步功能化,而氨基组则有利于引入含氮元素.该化合物在药用化学中对于建造受限制的消毒器和其他硬性脚架特别宝贵.在标准条件下,其稳定性确保了在合成工作流程中处理的便利.

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72784-42-0 66494-26-6 22059-21-8

上下游产品

methanol amin°Cyclopropane-1-carboxylic acid methyl 1-amin°Cyclopropane-1-carboxylate hydr°Chloride 1-(Benzhydrylidene-amino)-cyclopropanecarboxylic acid methyl estermethyl 2-aminobutanoate Methyl isobutyrate 2-amino-2-methylpropionic acid methyl ester ethene

合成工艺路线路线简述

  • 合成目标产物 Methyl 1-Aminocyclopropanecarboxylate 主要起始原料 Methanol And 1-Aminocyclopropanecarboxylic Acid
  • (文献来源)合成步骤主要原料 Methanol 和 1-Aminocyclopropanecarboxylic Acid
1-氨基环丙烷甲酸甲酯盐酸盐置于potassium Carbonate体系中,用 乙醚,水 作为反应溶剂,化学反应生成 1-氨基环丙基甲酸甲酯
参考文献:Decarboxylation Of 1-Aminocyclopropanecarboxylic Acid And Its Derivatives
标题:Decarboxylation Of 1-Aminocyclopropanecarboxylic Acid And Its Derivatives
摘要:
DOI:10.1021/jo00269A013

海关参考信息

专利信息


专利号:US-9351954-B2
优先权日:2009-12-04
标 题:Multicyclic compounds and methods of use thereof
发明人:SHAO LIMING; CAMPBELL JOHN EMMERSON; HEWITT MICHAEL CHARLES; CAMPBELL UNA; HANANIA TALEEN G
权利人:SUNOVION PHARMACEUTICALS INC; PGI DRUG DISCOVERY LLC
摘要:Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. For example, disclosed herein are compounds having formula (IIa) shown below, or a pharmaceutically acceptable salt or stereoisomer thereof, wherein the variables are defined herein. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

专利号:US-2008176865-A1
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人:BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:CN-104341450-A
优先权日:2013-08-09
标 题 :Synthesis and pharmaceutical application of a kind of sulfonamide derivative
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合成参考文献


参考文献:10.1007/s11627-023-10339-3
摘要:Li X, Fang P, Li M, Xu P. Identification of methyl 1-aminocyclopropanecarboxylate as a novel ethylene agonist: a structural analogy approach. In Vitro Cell.Dev.Biol.-Plant. 2023 Feb;59(1):61–73. doi: 10.1007/s11627-023-10339-3.
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