CAS: 71989-40-7; Fmoc-Tyr(Bzl)-Oh

该化合物是氨酸乙酰乙酰胺的一种受保护形式,通常用于丙酸合成."Fmoc"(9-氟甲基甲基甲基乙酰碳基)组是氨基功能的保护组,允许有选择的反应,而不会干扰氨基酸的再活性."O-苯基"修改保护了硫酸副链的氢氧基,加强了化合物的稳定性和溶解性.该物质一般是白色到白色的固体,溶于二甲基硫氧化物和二氯甲烷等有机溶剂,但水中的溶解度较低.其分子结构包括一个苯丙基氢氧化合物组,这有助于其再活动性和生物系统中的潜在相互作用.Fmoco-O-Benzyl-L-苯罗素在固态聚苯二硝基胺合成中广泛使用,因为它与各种混合试剂及其在保持氨基硫酸功能组的完整性的同时促进形成浸化物结.

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138775-48-1 16652-64-5 2130-96-3

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CAS号428868-52-4 Fm°C-N-甲基-O-苄基-酪氨酸 | CAS号103321-60-4 fm°C-o-benzyl-l...

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    专利号:US-12251674-B2
    优先权日:2012-11-14
    标 题:Substrates, systems, and methods for array synthesis and biomolecular analysis
    发明人:RAJASEKARAN JOHN J; JAYARAMAN VASANTH; WANG TIANHAO; BEI KANG; KRISHNAMURTHY HARI KRISHNAN; VEDANTHAM PUNITHA
    权利人:VIBRANT HOLDINGS LLC
    摘要:Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N→C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.

    专利号:US-8338565-B2
    优先权日:2008-08-20
    标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
    发明人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
    权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
    摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

    专利号:CN-104910257-A
    优先权日:2015-01-07
    标 题:The solid-phase synthesis method of goserelin acetate

    专利号:CN-102180964-A
    优先权日:2011-03-16
    标题:A kind of solid-phase synthesis method of human relaxin-2 Relaxin

    专利号:CN-104910257-B
    优先权日:2015-01-07
    标 题 :The solid phase synthesis process of Goserelin

    专利号:CN-110885360-A
    优先权日:2019-10-09
    标题:A kind of preparation method of solid-phase synthesis pasireotide

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    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

    合成参考文献


    参考文献:10.1055/s-0036-1588860
    摘要:Hu L, Zhao J. Ynamide: A New Coupling Reagent for Amide and Peptide Synthesis. Synlett. 2017 Jun 29;28(14):1663–70. doi: 10.1055/s-0036-1588860.
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