CAS: 55869-99-3; (1S,3S,5S,6S)-6-Hydroxy-8-Methyl-8-Azabicyclo[3.2.1]Octan-3-Yl (S)-3-Hydroxy-2-Phenylpropanoate
该化合物是一种来自亚硝基丁酸等植物的三氯丁二烯藻类,它作为一种抗胆碱酯酶剂,具有竞争性地阻塞肌肉骨髓乙酰胆碱受体,注意到该化合物对润滑肌肉,特别是胃肠道和下垂道的呼吸系统有影响,有助于治疗肠胃炎和阴道.此外,亚硝基胺通过对血液容器进行分层,表现出微循环性改善,这在休克管理中具有应用.它对于外围受体的选择性,将...
- 英文名称(1S,3S,5S,6S)-6-Hydroxy-8-Methyl-8-Azabicyclo[3.2.1]Octan-3-Yl (S)-3-Hydroxy-2-Phenylpropanoate
- 中文名称山莨菪碱
- IUPAC名称(1S,3S,5S,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (S)-3-hydroxy-2-phenylpropanoate
- 其它别名(1R-(1-Alpha,3-Beta(S*),5-Alpha,6-Alpha))-.1)Oct-3-Yleste; Atropine Impurity 5（atropine Ep Impurity E）; (1R,3S,5R,6Rs)-6-Hydroxy-8-Methyl-8-Azabicyclo[3.2.1]Oct-3-Yl (2S)-3-Hydroxy-2-Phenylpropanoate; Hyoscyamine Sulfate Impurity 3（hyoscyamine Sulfate Ep Impurity C）; Atropine Impurity E; Hyoscyamine, 6-Hydroxy- (6Ci, 7Ci); Aceanisodamine; Atropine Impurity E (7-Hydroxyhyoscyamine)
- CAS编号55869-99-3
- EINECS号:637-239-0
- FDA UNII编号:01343Q8EL8
- 分子式:C17H23NO4分子量:305.37
- 产品CID: 1530700
- 同类组份化合物CAS131674-05-0 (HCl)85760-60-7 (Racemic_free base)55869-99-3 (free base)55449-49-5 (HBr)
- 产品分类原料药 → 神经系统用药 → 拟胆碱药
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
scopolamine (-)-hyoscyamine hydrobromide (2S,3S)-di-4-toluoyltartaric acid 15H27NO3SiC15H27NO3Si(S)-tropic acid 3α,6β-dihydroxytropane HCl scopolamine (3R,6R)-tropane-3α,6β-diol合成工艺路线路线简述
📜氢溴酸天仙子胺置于alpha-酮戊二酸,Anisodus Tanguticus Hyoscyamine 6β-Hydroxylase,Iron(II) Sulfate体系中,用 Various Solvent(S) 作为反应溶剂,化学反应 2.0H,反应生成 山莨菪碱
参考文献:Molecular Cloning,Expression And Characterization Of Hyoscyamine 6β-Hydroxylase From Hairy Roots Ofanisodus Tanguticus
标题:Molecular Cloning,Expression And Characterization Of Hyoscyamine 6β-Hydroxylase From Hairy Roots Ofanisodus Tanguticus
摘要:唐古特茴香是茄科植物唐古特的本土药用植物之一,可产生抗胆碱能生物碱,如透明质酸,6δ²-羟基透明质酸和东莨菪碱.透明质酸 6δ²-羟化酶(h6H)是东莨菪碱生物合成途径中的一个关键酶,它催化透明质酸的羟化和 6δ²-羟基透明质酸环氧化物的形成,从而反应生成东莨菪碱.从唐古拉毛根中分离出了 H6H 的全长 Cdna.对克隆的 Cdna 进行核苷酸序列分析后发现,其开放阅读框长达 1035 Bp,编码 344 个氨基酸,与其他已知的 H6H 具有高度同源性.等效氨基酸序列显示了 2-氧代戊二酸依赖性二加氧酶的典型结构.在大肠杆菌中表达并纯化了唐古牛 H6H,以进行酶功能分析.这项研究对重组 Ath6H 进行了鉴定,结果表明它能从透明质酸反应生成东莨菪碱.
DOI:10.1055/s-2005-837825
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主要参考文献
1: Li S, Feng W, Chen D, Yu L, Cui H, Li M. Revealing the gastric protective mechanism of Physochlaina physaloides (L) G. Don. with clinical orientation: PPAR/NF-κB signalling pathway activation. Phytomedicine. 2025 Mar 16;141:156642. doi: 10.1016/j.phymed.2025.156642. Epub ahead of print. 15(1):8781. doi: 10.1038/s41598-024-84914-y.
3: Liang H, Yan H. Atropine plus omeprazole for acute gastritis: Efficacy and safety analysis. Pak J Pharm Sci. 2024 Nov-Dec;37(6):1207-1212.
289:117534. doi: 10.1016/j.ecoenv.2024.117534. Epub 2024 Dec 11. 24(22):7265. doi: 10.3390/s24227265.
合成参考文献
摘要:Zhonghua Yixue Zazhi. Chinese Medical Journal., 53(269), 1973
参考文献:10.1620/tjem.224.91
摘要:Wang Y, Fu X, Wang X, Jia X, Gu X, Zhang J, Su J, Hao G, Jiang Y, Fan W, Wu W, Li S. Protective effects of anisodamine on renal function in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Tohoku J Exp Med. 2011 Jun;224(2):91–7. doi: 10.1620/tjem.224.91.
参考文献:10.1016/j.foodchem.2020.127617
摘要:Wang Z, Zheng P, Wang J, He S, Ren Z, Zhang Y, Xiong J, Jiang H. Indirect competitive enzyme-linked immunosorbent assay based on a broad-spectrum monoclonal antibody for tropane alkaloids detection in pig urine, pork and cereal flours. Food Chem. 2021 Feb 01;337():127617. doi: 10.1016/j.foodchem.2020.127617.
摘要:Lu SF, Yu JL, Li YT. [Mechanism of anisodamine in the treatment of aplastic anemia]. Zhonghua Nei Ke Za Zhi. 1986 Jan;25(1):10–2, 62.
摘要:Zhu GJ, Xu SH, Xue QF, Chen HC. [The mechanism of inhibition of anisodamine on platelet aggregation induced by E. coli endotoxin]. Sheng Li Xue Bao. 1986 Jun;38(3):300–5.
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