CAS: 38215-36-0; 3-(Benzo[d]Thiazol-2-yl)-7-(Diethylamino)-2H-Chromen-2-One

该化合物是科马林合成衍生物,其特点是荧光特性,典型的是一种黄色至绿色粉末,可溶于乙醇和丙酮等有机溶剂,但在水中溶解性有限.该化合物以其在紫外线可见光谱中的强烈吸收而著称,在生物和化学研究中作为荧光染色剂等各种应用中有用.Coumarin 6显示出高量的产量,这增强了其在荧光显微镜和成像技术中的效用.此外,还研究了该化合物在光动力学治疗和环境研究中的潜在用途,认为该化合物毒性较低,但在实验室环境中处理时仍须遵守安全防范措施.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

2-(benzo[d]thiazol-2-yl)acetic acid 4-(Diethylamino)salicylaldehyde ethyl 2-(2-benzothiazolyl)acetate ethyl 2-cyanoacetate3-benzothiazol-2-yl-7-diethylamino-2-oxo-2H-chromene-4-carbonitrile

合成工艺路线路线简述

    📜4-(二乙氨基)水杨醛置于哌啶,盐酸,水体系中,化学反应 8.5H,反应生成 香豆素 6
    参考文献:新型有机铂(II)与喹啉-香豆素衍生物的体外和体内细胞毒性强.
    标题:新型有机铂(II)与喹啉-香豆素衍生物的体外和体内细胞毒性强.
    摘要:一系列新颖的有机铂(II)配合物[ptii(qc1)(h-Qc1)cl](pt1),[ptii(qc2)(h-Qc2)cl](pt2),[ptii(qc3)(h-Qc3)cl](pt3),[ptii(qc4)(h-Qc4)cl].ch3Oh(pt4),[ptii(qc5)(h-Qc5)cl](pt5),[ptii(h-Qc6)(Dmso)cl2](pt6),[ptii(h-Qc7)(dmso)cl2].h2O(pt7),[ptii(h-Qc8)(dmso)cl2](pt8),[ptii(h-Qc9)(Dmso)cl2].ch3Oh(pt9),[ptii(h-Qc10)(dmso)cl2](pt10)和[ptii(h-Qc11)(dmso)cl2](pt11),带有喹啉-香豆素衍生物(h-Qc1-H-Qc11)已被首先设计.与顺铂相比,复合物pt1-Pt11对a549 / Ddp(对
    DOI:10.1016/j.Ejmech.2019.111751

    海关参考信息

    专利信息


    专利号:US-12006540-B2
    优先权日:2015-09-28
    标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
    发明人:JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
    权利人:UNIV COLUMBIA
    摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

    专利号:US-9567430-B2
    优先权日:2011-12-02
    标 题 :Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
    发明人:SALTZMAN W MARK; JIANG ZHAOZHONG; ZHOU JIANGBING; LIU JIE
    权利人:UNIV YALE
    摘要:Poly(amine-co-ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the nanoparticles are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.

    专利号:US-11959137-B2
    优先权日:2015-09-28
    标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

    专利号:US-2024376536-A1
    优先权日:2015-09-28
    标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

    专利号:US-2022411860-A1
    优先权日:2015-09-28
    标题:Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

    专利号:US-2023160000-A1
    优先权日:2015-09-28
    标 题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Miao X, Et Al. Transport Mechanism Of Coumarin 6 Nanocrystals With Two Particle Sizes In Mdckii Monolayer And Larval Zebrafish. Acs Appl Mater Interfaces. 2016 May 25;8(20):12620-30.
    [参考文献]: Purr E, Et Al. Preparation Of Plga Nanoparticles Encapsulated With Fluorescent Probe Coumarin-6[参考文献]: Biorxiv, 2019: 614875.
    [参考文献]: Rivolta I, Et Al. Cellular Uptake Of Coumarin-6 As A Model Drug Loaded In Solid Lipid Nanoparticles. J Physiol Pharmacol. 2011 Feb;62(1):45-53.
    [参考文献]: Daniela Chirio, Et Al. Positive-Charged Solid Lipid Nanoparticles As Paclitaxel Drug Delivery System In Glioblastoma Treatment. Eur J Pharm Biopharm. 2014 Nov;88(3):746-58.
    [参考文献]: Dong-Yu Gao, Et Al. Cxcr4-Targeted Lipid-Coated Plga Nanoparticles Deliver Sorafenib And Overcome Acquired Drug Resistance In Liver Cancer. Biomaterials. 2015 Oct:67:194-203.

    合成参考文献


    参考文献:10.1016/j.ijpharm.2011.06.046
    摘要:Plajnšek KT, Pajk S, Govedarica B, Pečar S, Srčič S, Kristl J. A novel fluorescent probe for more effective monitoring of nanosized drug delivery systems within the cells. International Journal of Pharmaceutics. 2011 Sep;416(1):384–93. doi: 10.1016/j.ijpharm.2011.06.046.
    参考文献:10.1016/j.jconrel.2011.06.036
    摘要:Cu Y, Booth CJ, Saltzman WM. In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery. Journal of Controlled Release. 2011 Dec;156(2):258–64. doi: 10.1016/j.jconrel.2011.06.036.
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