CAS: 3397-33-9; 1-Benzyl 2-(2,5-Dioxopyrrolidin-1-yl) (S)-Pyrrolidine-1,2-Dicarboxylate

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N,N'-二琥珀酰亚胺基碳酸酯,N-苄氧羰基-L-脯氨酸置于吡啶体系中,用 乙腈 作为反应溶剂,化学反应生成 N-苄氧羰基-L-脯氨酸 N-羟基琥珀酰亚胺酯
参考文献:Synthesis Of Potent Water-Soluble Tissue Transglutaminase Inhibitors
标题:Synthesis Of Potent Water-Soluble Tissue Transglutaminase Inhibitors
摘要:Dipeptide-Based Sulfonium Peptidylmethylketones Derived From 6-Diazo-5-Oxo-L-Norleucine (Don) Have Been Investigated As Potential Water-Soluble Inhibitors Of Extracellular Transglutaminase. The Lead Compounds Were Prepared In Four Steps And Exhibited Potent Activity Against Tissue Transglutaminase. (C) 2008 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2008.09.006

专利信息

专利号:US-4244865-A
优先权日:1979-12-03
标题:α hydroxy tripeptide substrates
发明人：ALI AKHTAR; HILTIBRAN ROBERT G
权利人:ABBOTT LAB
摘要:This invention relates to the synthesis and use of novel α hydroxy tripeptide substrates which are useful in the quantitative determination of proteolytic enzymes such as thrombin and trypsin. In use, the disclosed substrates are hydrolyzed by a proteolytic enzyme to yield a moiety that can be evaluated spectrophotometrically to indicate the quantity of enzyme present.