5-硝基嘧啶置于氰胺,三乙胺体系中,用 乙醇 用作溶剂,化学反应 15.0H,以64%的收率获得2-氨基-5-硝基嘧啶 参考文献:Ring Transformations In Reactions Of Heterocyclic Compounds With Nucleophiles. Part 24. Pyrimidines. Part 86. Conversion Of 5-Nitropyrimidine Into 2-Substituted 5-Nitropyrimidine And 2-Amino-5-Nitropyridines By Amidines 标题:Ring Transformations In Reactions Of Heterocyclic Compounds With Nucleophiles. Part 24. Pyrimidines. Part 86. Conversion Of 5-Nitropyrimidine Into 2-Substituted 5-Nitropyrimidine And 2-Amino-5-Nitropyridines By Amidines 摘要: Doi:10.1021/jo00345A036
专利号:US-9090661-B2 优先权日:2009-03-27 标 题:Inhibitors of hepatitis C virus replication 发明人:COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:US-4093812-A 优先权日:1975-03-25 标 题:(Nitrofuryl)pyrazoles, their synthesis and use, and compositions containing them 发明人:RAINER GEORG 权利人:BYK GULDEN LOMBERG CHEM FAB 摘要:3-(5-Nitro-2-furyl)pyrazoles unsubstituted in the 5-position and 5-(5-nitro-2-furyl)pyrazoles unsubstituted in the 3-position are antimicrobials and disinfectants. The compounds are structurally represented by one of the formulae: ##STR1## wherein A is --CHO, --CN, --COOH, a protected or derived aldehyde group or a protected or derived carboxylic acid group; n B is 5-nitro-2-furyl; n R 1 is --H, substituted or unsubstituted hydrocarbyl (saturated or unsaturated; acyclic, alicyclic or aromatic; or araliphatic); substituted or unsubstituted (cycloaliphatic or aromatic) heterocyclic or acyl (carboxylic or carbonic acid); n R 2 is --H; and n n is a positive whole number of at most 2.
专利号:CN-101219997-B 优先权日:2008-01-02 标 题 :Synthesis of 2-chlorine-5- amido pyrimidine
专利号:CN-101219997-A 优先权日:2008-01-02 标题 :Synthesis of 2-chlorine-5- amido pyrimidine
专利号:JP-H06316576-A 优先权日:1983-04-11 标题 :Synthesis of 6,6-di-substituted dihydropteridine