CAS: 29216-28-2; 10-(Quinuclidin-3-Ylmethyl)-10H-Phenothiazine

上下游产品

CAS号151129-13-4 dehydromequitazine | CAS号151129-15-6 (E)-10-(1-azabi... | CAS号92-84-2 吩噻嗪 | CAS号86014-80-4 3-(chloromethyl... | CAS号87-69-4 酒石酸 | CAS号40765-34-2 10-(1-azabicycl...

Dehydromequitazine置于palladium 10% On Activated Carbon,氢气体系中,用 甲醇 用作溶剂,20.0 °C,101.33 Kpa 条件下,反应 24.0H,以91%的收率获得美喹他嗪
参考文献:Expedient Synthesis Of Mequitazine An Antihistaminic Drug By Palladium Catalyzed Allylic Alkylation Of Sodium Phenothiazinate
标题:Expedient Synthesis Of Mequitazine An Antihistaminic Drug By Palladium Catalyzed Allylic Alkylation Of Sodium Phenothiazinate
摘要:报告了一种简短而直接的抗组胺药物美克替嗪的合成方法,该方法基于在温和条件下,采用钯催化的烯丙基烷基化反应,将1-氮杂双环[2.2.2]辛-2-烯-3-基乙酸甲酯与苯噻嗪钠进行反应.
Doi:10.1248/cpb.57.1300

专利信息

专利号:US-8754074-B2
优先权日:2011-01-10
标题:Vinyl quinuclidine useful as a synthesis intermediate in the preparation of (R)-mequitazine
发明人：NICOLAS MARC; LARQUETOUX LAURENT; LEROUX SÉBASTIEN; DORIS ERIC
权利人:NICOLAS MARC; LARQUETOUX LAURENT; LEROUX SÉBASTIEN; DORIS ERIC; PF MEDICAMENT; COMMISSARIAT ENERGIE ATOMIQUE
摘要:The present invention relates to the use of the vinyl quinuclidine enantiomer (R) of the following formula 2 as a synthesis intermediate in the preparation of (R)-mequitazine.

专利号:US-8304545-B2
优先权日:2007-01-18
标 题:Quinuclidine derivative useful in the preparation of mequitazine
发明人：MIOSKOWSKI CHARLES; GONNOT VANESSA; BAATI RACHID; NICOLAS MARC
权利人:MIOSKOWSKI CHARLES; GONNOT VANESSA; BAATI RACHID; NICOLAS MARC; PF MEDICAMENT
摘要:The invention relates to a 1-aza-bicyclo[2.2.2]oct-2-en-3-ylmethyl acetate of the formula (I), wherein said compound is useful as a synthesis intermediate for the production of mequitazine.

专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

专利号:EP-1037891-B1
优先权日:1997-12-08
标 题 :Method for preparing mequitazine and novel synthesis intermediate
发明人：GUMINSKI YVES; IMBERT THIERRY; LESIMPLE PATRICK
权利人:PF MEDICAMENT
摘要:The invention concerns a novel method for preparing mequitazine and its laevo-gyrate isomer, consisting in reacting the phenothiazine derivative containing lithium with 3-methane sulphonyl oxymethyl-1-aza-bicyclo(2,2,2)-octane or its laevo-gyrate isomer, in the presence of butyllithium.

专利号:FR-2777278-A1
优先权日:1998-04-09
标 题:NOVEL PROCESS FOR THE PREPARATION OF 3-HYDROXYMETHYL QUINUCLIDINE INTERMEDIATE SYNTHESIS OF MEQUITAZINE

专利号:US-2006153882-A1
优先权日:2001-05-29
标题:Anti-allergic pharmaceutical composition containing at least one allergen and at least on antihistamine compound
发明人：LORIA EMILE; TERRASSE GAETAN; TREHIN YVES
权利人:LORIA EMILE; TERRASSE GAETAN; TREHIN YVES
摘要:The present invention relates to an anti-allergic pharmaceutical composition containing at least two active agents chosen among: (i) one allergen, (ii) one antihistamine compound, (iii) one inhibitor of histamine synthesis, said active agents being associated in said composition with a pharmaceutically acceptable vehicle.