CAS: 2616-72-0; 3-((4-Chloro-2-Methylphenyl)Carbamoyl)Naphthalen-2-Yl Dihydrogen Phosphate

该化合物是一种专门化染色物基质,广泛用于骨化学和免疫史化学污渍用途,用作磷酸酶基质,在酶水解中产生生动的红色黄星染,使其对检测组织部分中的碱性磷酸酶活动特别有价值;该产品具有高度的敏感性和特殊性,确保目标酶或抗体明确和精确地定位;在标准实验室条件下保持稳定,与各种检测系统兼容,增强了其在诊断和研究环境中的效用;Naphthol AS-TR Phosphate因其一贯的性能和产生耐久,高抗扰动性污点结果的能力而得到青睐.

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MSDS等安全信息

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ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

naphthol ASTR 3-Hydroxy-2-naphthoic acid 4-chloro-2-methylbenzeneamine

合成工艺路线路线简述

    📜2-羟基-3-萘甲酸置于五氯化磷,三氯化磷体系中,用 1,4-二氧六环 用作溶剂,化学反应 3.17H,反应生成萘酚as-Tr磷酸酯,游离萘酚
    参考文献:Fluorescent Substrates For Potential Use In Enzyme-Linked Immunosorbent Assay Of Membrane-Bound Nucleic Acids
    标题:Fluorescent Substrates For Potential Use In Enzyme-Linked Immunosorbent Assay Of Membrane-Bound Nucleic Acids
    摘要:A Number Of Phosphorylated Fluorochromes Were Synthesized And Tested For The Alkaline Phosphatase-Linked Fluorescence Assay Of Membrane-Bound Nucleic Acids. 3-Hydroxy-N-2'-Biphenyl-2-Naphthalenecarboxamide Phosphate Ester (Hbnp) Was Found To Be The Most Suitable For The Assay. Nonfluorescent Hbnp Is Hydrolyzed By Phospholipase Bound To The Probe Dna To The Highly Fluorescent 3-Hydroxy-N,2'-Biphenyl-2-Naphthalenecarboxamide (Hbn). Hbn Is Insoluble Enough In Aqueous Medium To Precipitate On The Nylon Membrane. Spots Containing As Little As 5 Fg Of Lambda Dna Can Be Successfully Detected On The Membrane With Hbnp.
    Doi:10.1021/ac00080A022

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    1: Lee JW, Park HS, Park SA, Ryu SH, Meng W, Jürgensmeier JM, Kurie JM, Hong WK, Boyer JL, Herbst RS, Koo JS. A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress. PLoS One. 2015 Apr 21;10(4):e0122628. doi: 10.1371/journal.pone.0122628. eCollection 2015.

    合成参考文献


    参考文献:10.1186/ar2877
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    参考文献:10.1007/bf00493118
    摘要:Korfsmeier KH. [Effect of hydroxyurea and 5-fluorouracil on enzyme pattern and ultrastructure of liver, kidney, and pancreas in rats (author's transl)]. Histochemie. 1974 Mar 06;38(3):203–10. doi: 10.1007/bf00493118.
    参考文献:10.1007/bf02008224
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