CAS: 24724-90-1; 2-Fucosamine

专利信息

专利号:US-8691776-B2
优先权日:2003-05-30
标 题:Synthesis of high molecular weight iron-saccharidic complexes
发明人：BECK ROBERT A; MATEER JR ROBERT A; KOWALSKI JOHN
权利人:BECK ROBERT A; MATEER JR ROBERT A; KOWALSKI JOHN; CHROMACEUTICAL ADVANCED TECH
摘要:A process for preparing parenteral iron-saccharidic complexes, and the complexes produced, comprising: (1) providing an aqueous solution or dispersion including (i) Fe(III) and (OH) − ions and (ii) at least one saccharide, to form a reaction mixture, where the molar ratio of (i):(ii) is about 30:1 to about 1:30; and the mixture temperature and pH are at or above the complex assembly point (CAP); and (2) maintaining temperature and pH at or above the CAP for a time sufficient to form an iron-saccharidic complex having a molecular weight of about 25,000 Daltons or more. Control of the temperature and pH efficiently produces a high molecular weight complex. The complex can be separated by precipitation, dialysis and/or column fractionation and, if desired, dried, e.g., lyophilized or spray dried. The process can controllably synthesize complexes of varying molecular weight and/or chemical composition, particularly sodium ferric gluconate and ferric hydroxide-sucrose.

专利号:US-10001488-B2
优先权日:2013-04-03
标 题:Synthesis and use of isotopically-labelled glycans
发明人：REICHARDT NIELS-CHRISTIAN; ECHEVERRÃ?A BEISTEGUI BEGOÑA-MARIA; ETXEBARRIA JUAN; CALVO JAVIER; RUIZ NEREA
权利人:ASOCIACION CENTRO DE INVESTIG COOPERATIVA EN BIOMATERIALES; ASOCACION CENTRO DE INVESTIG COOPERATIVA EN BIOMATERIALS
摘要:Isotopically-labelled glycans and their synthesis and use as internal standards in the analysis by mass spectrometry of glycan mixtures is described. The methods of synthesis described herein may be used conveniently to prepare libraries of heavy glycans for use in the qualitative and quantitative identification of glycans in natural samples.

专利号:US-2014170151-A1
优先权日:2010-04-23
标 题:Synthetic Oligosaccharides for Staphylococcus Vaccine
发明人：CAMPBELL A STEWART; PLANTE OBADIAH J
权利人:CAMPBELL A STEWART; PLANTE OBADIAH J
摘要:The present invention synthetic oligo-β-(1→6)-glucosamine structures and a methodology which essentially allows for the synthesis of any oligo-β-(1→6)-glucosamine species having a definite number of monosaccharide units, including a set pattern of acetylated and non-acetylated residues. The invention further provides antibodies to these synthetic oligo-β-(1→6)-glucosamines as well as compositions thereof and methods for treating and preventing infections caused by bacteria expressing poly-β-(1→6)-glucosamines, such as Staphylococcus aureus.

专利号:CA-2526771-C
优先权日:2003-05-30
标题 :Synthesis of high molecular weight iron-saccharidic complexes

专利号:EP-1628986-B1
优先权日:2003-05-30
标 题 :Synthesis of high molecular weight iron-saccharidic complexes

专利号:US-2005037996-A1
优先权日:2003-05-30
标题:Synthesis of high molecular weight iron-saccharidic complexes