CAS: 24582-91-0; Elenolide

专利信息

专利号:US-3703530-A
优先权日:1970-08-24
标 题 :Alkyl - 2 - alkyl - 2,3 - dicarboxy-5-norbornene - 7-acetate intermediates for the total synthesis of elenolic acids and analogs thereof
发明人：KELLY ROBERT C
权利人:UPJOHN CO
摘要:A TOTAL SYNTHESIS OF ELENOLIC ACID, FORMULA XIV (R AND R2 ARE HYDROGEN, R1 AND R3 ARE METHYL) AND THE ANALOGS THEREOF, OF FORMULA XIV: 3-(R3-O-),4-(R-OOC-CH(-R2)-),5-(HCO-),6-R1-5,6-DIHYDRO- 4H-PYRAN WHEREIN R AND R3 ARE ALKYL OF 1 TO 8 CARBON ATOMS, INCLUSIVE, WHEREIN R1 IS ALKYL OF 1 TO 4 CARBON ATOMS, INCLUSIVE, AND WHEREIN R2 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND ALKYL OF 1 TO 4 CARBON ATOMS, INCLUSIVE, IS CARRIED OUT BY A MULTI-STEP PROCESS STARTING FROM CYCLOPENTADIENE. COMPOUNDS OF FORMULA XIV HAVE VIRUCIDAL AND HYPOTENSIVE ACTIVITY AND CAN BE USED AS HYPOTENSIVE AGENTS IN MAMMALS (U.S. PAT. 3,033,877) OR AS VIRUCIDAL AGENTS TO DECONTAMINATE SURGICAL INSTRUMENTS, HOSPITAL WALLS, SWIMMING POOLS, OR CAN BE USED FOR NASAL WASHES IN MAMMALS.

专利号:US-3793346-A
优先权日:1970-08-24
标 题:Intermediate in the total synthesis of elenolic acid
发明人：KELLY R
权利人:UPJOHN CO
摘要:A COMPOUND OF THE FORMULA 2-R4,2-R5,4-(R1-CH(-OH),5-(R-OOC-CH(-R2),6-(R3-OOC-)- 4,5,6,6A-TETRAHYDRO-3AH-CYCLOPENTA-1,3-DIOXOLE WHEREIN R AND R3 ARE ALKYL OF 1 TO 3 CABON ATOMS, INCLUSIVE, R1 IS ALKYL OF 1 TO 4 CARBON ATOMS R2 IS HYDROGEN OR ALKYL OF 1 TO 4 CARBON ATOMS, AND R4 AND R5 ARE HYDROGEN, ALKYL OF 1 TO 4 CARBON AOMS, INCLUSIVE, OR PHENYL, WITH THE PROVISO THAT ONLY ONE OF R4 AND R5 IS PHENYL, IS PRODUCED IN A MULTISTEP REACTION. THE COMPOUND IS AN INTERMEDIATE FOR ELENOLIC ACID.

专利号:US-3786068-A
优先权日:1970-08-24
标 题:Intermediate in the total synthesis of elenolic acid
发明人：KELLY R
权利人:UPJOHN CO
摘要:A COMPOUND OF THE FORMULA: 2-R4,2-R5,5-R1,8-(R2-CH(-COO-R)-)-3A,4,7,7A-TETRAHYDRO- 4,7-METHANO-1,3-BENZODIOXOLE WHEREIN R IS ALKYL OF 1 TO 8 CARBON ATOMS, INCLUSIVE, R1 IS ALKYL OF 1 TO 4 CARBON ATOMS, R2 IS HYDROGEN OR ALKYL OF 1 TO 4 CARBON ATOMS, AND R4 AND R5 ARE HYDROGEN, ALKYL OF 1 TO 4 CARBON ATOMS, INCLUSIVE OR PHENYL, WITH THE PROVISO THAT ONLY ONE OF R4 AND R5 IS PHENYL, IS PRODUCED IN A MULTISTEP REACTION. THE COMPOUND IS AN INTERMEDIATE FOR ELENOLIC ACID.

专利号:US-3770777-A
优先权日:1970-08-24
标 题:2-hydroxy - 3 - (1-hydroxyethyl)-5-carboxy - 3,4 - dihydro-2h-pyran-4-acetic acid 4,5-dimethyl ester, 3-methanesulfonate
发明人：KELLY R
权利人:UPJOHN CO
摘要:WHEREIN R AND R3 ARE ALKYL OF 1 TO 8 CARBON ATOMS, INCLUSIVE, WHEREIN R1 IS ALKYL OF 1 TO 4 CARBON ATOMS, INCLUSIVE, AND WHEREIN R2 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND ALKYL OF 1 TO 4 CARBON ATOMS, INCLUSICVE IS CARRIED OUT BY A MULTI-STEP PROCESS STARTING FROM CYCLOPENTADIENE. COMPOUNDS OF FORMULA XIV HAVE VIRUCIDAL AND HYPOTENSICVE ACTIVITY AND CAN BE USED AS HYPOTENSIVE AGENTS IN MAMMALS (U.S.PAT.3,033,877) OR AS VIRUCIDAL AGENTS TO DECONTAMINATE SURGICAL INSTRUMENTS, HOSPITAL WALLS, SWIMMING POOLS, OR CAN BE USED FOR NASAL WASHES IN MAMMALS. 2H-PYRAN 2-R1,3-(O=CH-),4-(R-OOC-CH(-R2)-),5-(R3-OOC-)-3,4-DIHYDRO- A TOTAL SYNTHESIS OF ELENOLIC ACID, FORMULA XIV (R AND R2 ARE HYDROGEN, R1 AND R3 ARE METHYL) AND THE ANALOGS THEREOF, OF FORMULA XIV: