CAS: 23429-44-9; (Chloro(P-Tolyl)Methylene)Dibenzene

上下游产品

CAS号5440-76-6 二苯基(对甲苯基)甲醇 | CAS号106-38-7 对溴甲苯 | CAS号119-61-9 二苯甲酮 | CAS号108-86-1 溴苯 | CAS号134-84-9 4-甲基二苯甲酮 | CAS号108-88-3 甲苯 | CAS号147246-89-7 diphenyl-p-toly... | CAS号603-37-2 对甲基三苯基甲烷

4-甲基二苯甲酮置于氯化亚砜,Magnesium体系中,用 四氯化碳 用作溶剂,化学反应 6.0H,反应生成4-甲基三苯基氯甲烷
参考文献:三苯甲基胺向亚胺的碱基诱导重排:机理的发现和研究
标题:三苯甲基胺向亚胺的碱基诱导重排:机理的发现和研究
摘要:在制备伯胺的过程中,在n-烷基三苯甲基胺的形成过程中,用n-Buli和烷基卤化物处理三苯甲基胺时,分离出了一种出人意料的化合物,即苯胺衍生的二苯甲酮亚胺.对于该碱诱导的三苯甲基胺重排以产生相应的亚胺,提出了三苯甲基酰胺的氮阴离子对相邻的c键联的苯基上的取代或未取代的亲电子攻击,涉及桥接的阴离子中间体.芳香环中的吸电子基团有利于负电荷的发展,影响相对迁移趋势.
Doi:10.1016/j.Tet.2007.03.055

专利信息

专利号:US-2008287649-A1
优先权日:2006-12-29
标 题 :Methods for the synthesis of cyclic peptides
发明人：CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
权利人:CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
摘要:Methods for the synthesis of cyclic peptides are provided, as well as novel dipeptide compounds. The methods include the solid phase synthesis of a dipeptide, which is the coupled to a second peptide in a solid phase reaction. The peptide is then cyclized following the coupling reaction. The methods and dipeptides are particularly useful for the synthesis of MC-4 receptor agonist peptides.

专利号:EP-1960423-B1
优先权日:2004-12-30
标 题:Synthesis of peptide t-20 using peptide intermediate fragments
发明人：HAN YEUN-KWEI; JOHNSTON DAVID A; KHATRI HIRALAL N
权利人:HOFFMANN LA ROCHE
摘要:Methods for the solid phase synthesis of T-20 peptides and peptide intermediates, in particular methods involving synthesizing T-20 peptide intermediates at low loading factors to produce products having excellent purity and yield.

专利号:US-9115179-B2
优先权日:2012-06-22
标题 :Synthesis of beta-turn peptidomimetic cyclic compounds
发明人：LAMA TERESA; PASCAL JEANICK
权利人:MIMETOGEN PHARMACEUTICALS INC
摘要:The present invention relates to methods of preparing β-turn cyclic peptidomimetic compounds and intermediates thereof. Particularly, the present invention relates to a process for the synthesis of β-turn cyclic peptidomimetic compounds of formula I: n nwhere R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , L 2 , X, Y and n are as defined in the specification.n n The present invention provides a more efficient route for preparing β-turn cyclic peptidomimetic compounds and intermediates thereof.

专利号:EP-1833843-B1
优先权日:2004-12-30
标 题:Synthesis of peptide t-20 using peptide intermediate fragments
发明人：HAN YEUN-KWEI; JOHNSTON DAVID A; KHATRI HIRALAL N
权利人:HOFFMANN LA ROCHE
摘要:Methods for the solid phase synthesis of T-20 peptides and peptide intermediates, in particular methods involving synthesizing T-20 peptide intermediates at low loading factors to produce products having excellent purity and yield.

专利号:US-7544665-B2
优先权日:2004-12-30
标题 :Synthesis using peptide intermediate fragments
发明人：KHATRI HIRALAL N; HAN YEUN-KWEI; JOHNSTON DAVID A; HODGES L MARK
权利人:ROCHE COLORADO CORP
摘要:Methods for the solid phase synthesis of T-1249 peptides and peptide intermediates, in particular methods involving synthesizing T-1249 peptide intermediates at low loading factors to produce products having excellent purity and yield.

专利号:US-8227571-B2
优先权日:2007-12-11
标题 :Insulinotropic peptide synthesis using solid and solution phase combination techniques
发明人：CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
权利人:CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R; ROCHE PALO ALTO LLC
摘要:The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybridâ€?) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to the third fragment which is then coupled to the second fragment and then the first fragment in solution. Alternatively, a different second fragment is coupled to the first fragment in the solid phase. Then, solution phase chemistry is then used to add additional amino acid material to a different third fragment. Subsequently, this different third fragment is coupled to the coupled first and different second fragment in the solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to the other fragments. The present invention is very useful for forming insulinotropic peptides such as GLP-1(7-36) and its natural and non-natural counteparts.