CAS: 21427-61-2; 5-Chloro-2-Hydroxy-3-Nitropyridine

相似化合物

6332-56-5 22353-38-4 92138-35-7

上下游产品

CAS号1072-98-6 2-氨基-5-氯吡啶 | CAS号4214-79-3 5-氯-2-吡啶醇 | CAS号5409-39-2 2-氨基-5-氯-3-硝基吡啶 | CAS号7664-93-9 硫酸 | CAS号7697-37-2 硝酸 | CAS号90902-83-3 2-溴-3-氨基-5-氯吡啶 | CAS号181123-11-5 5-氯-2-氰基-3-硝基吡啶 | CAS号78607-32-6 2,5-二氯-3-氨基吡啶 | CAS号98027-36-2 2羟基3氨基5氯吡啶 | CAS号75806-86-9 5-氯-2-溴-3-硝基吡啶 | CAS号21427-62-3 2,5-二氯-3-硝基吡啶 | CAS号27330-34-3 3-氨基-5-氯吡啶-2-酰胺 | CAS号856834-36-1 5-氯-3-硝基吡啶甲酰胺 | CAS号408538-29-4 3-氨基-5-氯氰基吡啶

5-氯-2-羟基吡啶置于硫酸,硝酸体系中,用 水 用作溶剂,化学反应 18.0H,反应生成5-氯-2-羟基-3-硝基吡啶
参考文献:作为氨基糖原合酶激酶3(gsk-3)抑制剂的8-氨基-[1,2,4]三唑并[4,3-A ]吡啶-3(2 H)-One衍生物的合成与评价
标题:作为氨基糖原合酶激酶3(gsk-3)抑制剂的8-氨基-[1,2,4]三唑并[4,3-A ]吡啶-3(2 H)-One衍生物的合成与评价
摘要:通过建模,合成设计了新的强力糖原合酶激酶3(gsk-3)抑制剂8-氨基-[1,2,4]三唑并[4,3-A ]吡啶-3(2 H)-One衍生物.并进行了体外评价.化合物17C在基于酶和细胞的测定中显示出非常好的效价(ic 50 = 111 Nm,Ec 50 = 1.78μm).此外,已证明其具有理想的水溶性,Pk曲线和适度的大脑渗透能力.
Doi:10.1016/j.Bmcl.2013.03.119

专利信息

专利号:US-9815842-B2
优先权日:2014-05-28
标题 :Pyrazolo pyrimidine derivatives and their use as MALT1 inhibitors
发明人：SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS
权利人:SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS; NOVARTIS AG
摘要:The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

专利号:CN-101830845-A
优先权日:2010-05-28
标 题 :Synthesis method of 5-chloro-2,3-dihydroxyl pyridine