CAS: 210532-25-5; 3,5-Difluorobenzene-1-Sulfonyl Chloride

上下游产品

3,5-difluoroaniline 3,5-difluorobenzenesulfonamide H-carbazol-2-yloxy]-acetic acid tert-butyl ester[9-(3,5-difluoro-benzenesulfonyl)-9H-carbazol-2-yloxy]-acetic acid tert-butyl ester benzyl 2-(6-chloro-9-(3,5-difluorophenylsulfonyl)-9H-carbazol-2-yl)propanoate 8-(3,5-difluorophenylsulfonylamino)quinoline

3,5-二氟苯胺置于氯化亚铜 盐酸,溶剂黄146,Sodium Nitrite体系中,用 水 用作溶剂,化学反应生成3,5-二氟苯磺酰氯
参考文献:Nitromethylthiobenzene Derivatives As Inhibitors Of Aldose Reductase
标题:Nitromethylthiobenzene Derivatives As Inhibitors Of Aldose Reductase
摘要:本发明涉及一种通用公式(1)的新化合物,其中:P,T1,T2,X和n定义如权利要求1所述,它们的互变异构体,以及它们与药用可接受碱的可加性盐.本发明还涉及制备这些化合物的方法及其作为药物的应用.这些化合物抑制aldose还原酶酶,可用于治疗或预防周围性和自主性神经糖尿病并发症,肾脏和眼科疾病,如白内障和视网膜病变.

专利信息

专利号:US-10675366-B2
优先权日:2016-08-12
标 题 :Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase M2
发明人：BEINAT CORRINE GAYE; ALAM ISRAT SHAMIMA; JAMES MICHELLE L; GAMBHIR SANJIV S; SRINIVASAN ANANTH
权利人:UNIV LELAND STANFORD JUNIOR
摘要:The present disclosure provides a positron emission tomography (PET)-detectable 1-((2-fluoro-6-[18F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([18F]DASA-23) probe that can selectively bind to the pyruvate kinase variant M2 (PKM2) found in cancer cells, such as of human glioma. Given the importance of PKM2 in the regulation of tumor metabolism, there is an on-going need to non-invasively measure its expression through the development of PKM2-specific radiopharmaceuticals. Precursors useful for the synthesis of the radiolabeled [18F]DASA-23-PKM2-specific probe and related compounds, and their methods of synthesis, are provided. Since the half-life of the 18F isotope is approximately 110 min, it is advantageous for a practitioner to attach the radionuclide to the precursor shortly before administration. Therefore, a precursor compound suitable for receiving the radionuclide and capable of specifically binding to the PKM2 variant can be provided.

专利号:CN-119320374-A
优先权日:2024-11-04
标 题 :A method for photocatalytic synthesis of 3-sulfonyl-substituted chromone derivatives

专利号:RU-2184110-C2
优先权日:1996-12-23
标 题 :Derivatives of nitromethylthiobenzene, method of their synthesis (versions) and pharmaceutical composition