CAS: 207994-08-9; 5-Chloro-3-Fluoropicolinic Acid

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214055-12-6 207994-11-4 214055-11-5

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CAS号124-38-9 二氧化碳 | CAS号514797-98-9 5-氯-3-氟-2-碘吡啶 | CAS号514797-97-8 2-溴-5-氯-3-氟吡啶 | CAS号89402-43-7 2,3-二氟-5-氯吡啶 | CAS号514797-96-7 2-羟基-3-氟-5-氯吡啶 | CAS号514798-05-1 2-溴-5-氯-3-氟-4-碘吡啶 | CAS号514798-06-2 5-chloro-3-fluo... | CAS号214055-12-6 (5-chloro-3-flu... | CAS号207994-09-0 2-Pyridinecarbo...

📜2-溴-3-氟-5-氯吡啶置于正丁基锂,异丙基氯化镁体系中,用 四氢呋喃,正己烷,甲苯 用作溶剂,化学反应 4.0H,反应生成5-氯-3-氟-2-吡啶羧酸
参考文献:Creating Structural Manifolds From A Common Precursor: Basicity Gradient-Driven Isomerization Of Halopyridines
标题:Creating Structural Manifolds From A Common Precursor: Basicity Gradient-Driven Isomerization Of Halopyridines
摘要:5-Chloro-2,3-Difluoropyridine,An Intermediate In The Manufacturing Process Of An Industrial Pesticide,Can Be Hydrolyzed To 5-Chloro-3-Fluoro-2H-Pyridinone And The Latter Converted Into 2,5-Dichloro-3-Fluoropyridine (1A),2-Bromo-5Chloro-3-Fluoropyridine (1B),5-Chloro-3-Fluoro-2-Iodopyridine (1C) And 3-Chloro-5-Fluoropyridine (1D). Consecutive Treatment Of These Four Substrates With Lithium Diisopropylamide And Carbon Dioxide Or Lithium Diisopropylamide And Iodine Affords The Corresponding 4-Pyridinecarboxylic Acids 2 And 4-Iodopyridines 3,Respectively. Amide-Promoted Deprotonation Of Such 4-Iodopyridines 3 Triggers An Isomerization In Which Lithium And Iodine Change Places. The Resulting Species Can Be Trapped With Carbon Dioxide To Give The Acids 5A-C Or Neutralized To Give The Halopyridines 4A-C. The Iodopyridines 4A And 4B Can Be Converted Into The Acids 6A And 6B,The Latter Product Leading Also To The Congeners 6C And 6D. The Diiodopyridine 4C Provides An Entry To The Halopyridine 4D,Which At The Same Time May Act As The Precursor To The Acid 5D,The Acid 7 Or The Bisacid 8. Finally,The Acid 9 Is Accessible From Either One Of The 5-Chloro-3-Fluoro-2-Halopyridines 1B And 1C. (C) Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2002).
Doi:10.1002/1099-0690(200212)2002:24<4174::Aid-Ejoc4174>3.0.Co;2-6