专利号:US-2005032187-A1 优先权日:2003-08-01 标题:Novel peptide-forming enzyme, microbe producing the enzyme and method for producing peptide using them 发明人:YOKOZEKI KENZO; SUZUKI SONOKO; HARA SEIICHI; KATAYAMA SATOSHI 权利人:AJINOMOTO KK 摘要:The present invention relates to a novel enzyme that allows peptide to be produced easily, inexpensively and at high yield without going through a complex synthesis method. More particularly, the present invention provides a novel enzyme that catalyzes a peptide-producing reaction from a carboxy component and an amine component, a microbe that produces the enzyme, and a method for inexpensive production of peptides using this enzyme or microbe. The novel enzyme that efficiently produces peptide was discovered from a newly discovered microbe belonging to the genus Empedobacter , and a method was found that allows peptides to be produced inexpensively and easily.
专利号:US-2005032154-A1 优先权日:2002-07-26 标题 :Method for producing tripeptides and/or peptides longer than tripeptides 发明人:YOKOZEKI KENZO; SUZUKI SONOKO; HARA SEIICHI; ABE ISAO 权利人:AJINOMOTO KK 摘要:It is an object of the present invention to provide a method that allows the production of peptides that are equal to or longer than tripeptides easily, inexpensively and at high yield without going through a complex synthesis method. The inventors of the present invention have found a novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium . In the present invention, this enzyme is allowed to act on a carboxy component and an amine component to produce peptides that are equal to or longer than tripeptides.
专利号:US-7749742-B2 优先权日:2002-07-26 标 题:Method for producing tripeptides and/or peptides longer than tripeptides 发明人:YOKOZEKI KENZO; SUZUKI SONOKO; HARA SEIICHI; ABE ISAO 权利人:AJINOMOTO KK 摘要:A method is disclosed that allows the production of peptides having three or more amino acid residues easily, inexpensively and at high yield without going through a complex synthesis method. A novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium is provided. The enzyme acts on a carboxy component and an amine component to form peptides having three or more amino acid residues by acting on a carboxy component and an amine component.
参考标题:Formal Synthesis Of (+)-Lactacystin From L-Serine 作者:Philip C. Bulman Page,Ross L. Goodyear,Yohan Chan,Alexandra M. Z. Slawin,Steven M. Allin 摘要:A Formal, Stereocontrolled Synthesis Of Lactacystin Has Been Completed From T-Bu-O-L-Serine, Providing The Key Intermediate 13, Also Useful For The Generation Of A Range Of C-9 Analogues.