CAS: 15641-58-4; 2,2,3,3-Tetramethylcyclopropanecarboxylic Acid

该化合物是一种具有独特四甲基替代环形结构特征的有严重障碍的环丙烷衍生物,该化合物因其稳定性和僵硬性而备受重视,成为有机合成的有用中间体,特别是用于开发特殊化学品和药品.高替代环丙烷环具有严重的不育障碍,可影响合成应用中的再活性和选择性.其碳oxy酸功能允许进一步衍生,使其得以用于培养酯类,氨基和其他功能化化合物.该化合物的结构特征也使其对设计受限分子结构的材料科学感兴趣.

结构式图片

相似化合物

497-42-7 75885-59-5 16340-68-4

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合成工艺路线路线简述

  • 合成目标产物 2,2,3,3-Tetramethylcyclopropanecarboxylic Acid 主要起始原料 2,3-Dimethyl-2-Butene
  • (文献来源)合成步骤主要原料 2,3-Dimethyl-2-Butene
2,3-二甲基-2-丁烯置于氢氧化钾,铜体系中,用 甲醇 用作溶剂,化学反应生成2,2,3,3-四甲基环丙甲酸
参考文献:.Alpha.,.Alpha.,2,2,3,3-Hexamethylcyclopropylcarbinyl System. Carbonium Ion Behavior In Nucleophilic And Superacid Solvents
标题:.Alpha.,.Alpha.,2,2,3,3-Hexamethylcyclopropylcarbinyl System. Carbonium Ion Behavior In Nucleophilic And Superacid Solvents
摘要:
Doi:10.1021/ja00762A022

海关参考信息

专利信息


专利号:US-9487471-B1
优先权日:2014-04-14
标题 :Synthesis of pyrethroids and pyrethroid-containing compositions
发明人:COELHO PEDRO; MEINHOLD PETER; CHEN MIKE M Y
权利人:PROVIVI INC
摘要:The present invention provides methods for synthesizing pyrethroid compounds. The methods include forming a first reaction comprising an olefin and an allethrolone-type unsaturated alcohol under conditions sufficient to form a metathesis product and converting the metathesis product to the pyrethroid. Methods of the invention can be used to prepare compounds including pyrethrin I, cinerin I, jasmolin I, pyrethrin II, cinerin II, and jasmolin II as well as other synthetic pyrethroid compounds. Insecticidal compositions and methods for controlling insects are also described.

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人:ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:US-5925676-A
优先权日:1996-09-13
标题 :Ester compounds pesticidal compositions containing the same and itermediates for synthesis thereof
发明人:IWASAKI TOMONORI; TSUSHIMA KAZUNORI; SUGANO MASAYO
权利人:SUMITOMO CHEMICAL CO
摘要:An ester compound represented by the formula ##STR1## wherein R 1 and R 2 may be the same or different and each represent a C 1 -C 6 alkyl group, or other specified groups, which may be optionally substituted with one or more halogen atoms; and R 3 represents a pyrethroid acid residue (a group resulting from elimination of the carboxyl group from pyrethroid acid), and a pesticidal composition containing the ester compound as an active ingredient.

专利号:US-8163773-B2
优先权日:2005-07-11
标题 :Organic compounds
发明人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI
权利人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI; NOVARTIS AG
摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1, R2, T, R3 and R4 are as defined in the specification.
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主要参考文献

[参考文献]: Neta Pessah, Et Al. Alpha-Fluoro-2,2,3,3-Tetramethylcyclopropanecarboxamide, A Novel Potent Anticonvulsant Derivative Of A Cyclic Analogue Of Valproic Acid. J Med Chem. 2009 Apr 23;52(8):2233-42.
[参考文献]: Sara Eyal, Et Al. Histone Deacetylases Inhibition And Tumor Cells Cytotoxicity By Cns-Active Vpa Constitutional Isomers And Derivatives. Biochem Pharmacol. 2005 May 15;69(10):1501-8.
[参考文献]: Tawfeeq Shekh-Ahmad, Et Al. Synthesis And Anticonvulsant Evaluation Of Dimethylethanolamine Analogues Of Valproic Acid And Its Tetramethylcyclopropyl Analogue. Epilepsy Res. 2012 Feb;98(2-3):238-46.

合成参考文献


摘要:Zhang, F.-L.; Wang, Y.-F., Science of Synthesis: Advances in Organoboron Chemistry towards Organic Synthesis, (2019) 1, 385.
摘要:Panda, S. P.; Hota, S. K.; Jindal, A.; Murarka, S., Science of Synthesis: Base-Metal Catalysis, (2023) 2, 20.
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